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坎地沙坦酯

坎地沙坦酯用途

Candesartan Cilexetil (TCV-116)是血管紧张素II拮抗剂,可用于高血压。

坎地沙坦酯名称

[ CAS 号 ]:
145040-37-5

[ 中文名 ]:
坎地沙坦酯

[ 英文名 ]:
Candesartan cilexetil

[中文别名 ]:

坎地沙坦西来替昔酯

[英文别名 ]:

Candesartan cilexetil
UNII:R85M2X0D68
MFCD00871371
Candesartan (Cilexetil)

坎地沙坦酯生物活性

[ 描述 ]:

Candesartan Cilexetil (TCV-116)是血管紧张素II拮抗剂,可用于高血压。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管紧张素受体

研究领域 >> 心血管疾病

[参考文献]

[1]. Pfeffer, M.A., et al., Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet, 2003. 362(9386): p. 759-66.

[2]. Wada, T., et al., Comparison of the antihypertensive effects of the new angiotensin II (AT1) receptor antagonist candesartan cilexetil (TCV-116) and the angiotensin converting enzyme inhibitor enalapril in rats. Hypertens Res, 1996. 19(2): p. 75-81.

[相关活性小分子]

坎地沙坦酯物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
843.3±75.0 °C at 760 mmHg

[ 熔点 ]:
168-170?C

[ 分子式 ]:
C₃₃H₃₄N₆O₆

[ 分子量 ]:
610.660

[ 闪点 ]:
463.8±37.1 °C

[ 精确质量 ]:
610.253967

[ PSA ]:
143.34000

[ LogP ]:
7.79

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 蒸汽压 ]:
0.0±3.1 mmHg at 25°C

[ 折射率 ]:
1.667

[ 储存条件 ]:
-20°C Freezer

[ 水溶解性 ]:
微溶：甲醇；极微溶：乙醇

坎地沙坦酯MSDS

坎地沙坦酯安全信息

[ 符号 ]:

GHS08, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H361-H400

[ 警示性声明 ]:
P280

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933990090

坎地沙坦酯合成路线

坎地沙坦酯上下游产品

坎地沙坦酯上游产品

坎地沙坦酯下游产品

坎地沙坦酯海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

坎地沙坦酯文献

Development and characterization of mixed niosomes for oral delivery using candesartan cilexetil as a model poorly water-soluble drug.

AAPS PharmSciTech 16(1) , 108-17, (2015)

The aim of this study was to prepare candesartan cilexetil-loaded niosomes and mixed niosomes to enhance the aqueous solubility of the drug, thus improving its oral bioavailability. The formulations w...

Use of compounded dispersing media for extemporaneous pediatric syrups with candesartan cilexetil and valsartan.

Acta. Pharm. 64(4) , 463-74, (2014)

Available tablets or capsules for adults are often used to prepare extemporaneously formulated medicines appropriate for children. The most acceptable drug forms in pediatric population are oral liqui...

Hepatic, intestinal, renal, and plasma hydrolysis of prodrugs in human, cynomolgus monkey, dog, and rat: implications for in vitro-in vivo extrapolation of clearance of prodrugs.

Drug Metab. Dispos. 42(9) , 1522-31, (2014)

Hydrolysis plays an important role in metabolic activation of prodrugs. In the current study, species and in vitro system differences in hepatic and extrahepatic hydrolysis were investigated for 11 pr...

更多文献

坎地沙坦酯相关知识

坎地沙坦酯片-说明书-作用-坎地沙坦酯副作用

2019-01-03 23:01:56

导读：坎地沙坦酯为ARB类降压药（俗称沙坦类降压药），这类降压药是目前临床上常用的一类降压药，是一类高效，长效，安全的新型降压药；坎地沙坦酯的降压持续时间更长，坎地沙坦酯的谷峰比值更高，降压更加平稳，能保持24小时平稳控制血压，血压波动小；高血压合并糖尿病的患者就要选择坎地沙坦酯，因为该药能增强胰...