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N-乙酰基-酪氨酰-缬氨酰-丙氨酰-天冬氨酸-7-氨基-4-甲基香豆素

名称

[ CAS 号 ]:
149231-65-2

[ 中文名 ]:
N-乙酰基-酪氨酰-缬氨酰-丙氨酰-天冬氨酸-7-氨基-4-甲基香豆素

[ 英文名 ]:
Ac-Tyr-Val-Ala-Asp-AMC

[中文别名 ]:

蛋白酶1底物2m.荧光

[英文别名 ]:

acetyl-YVAD-aminomethyl coumarine
Ac-Tyr-Val-Ala-Asp-7-Amino-4-Methylcoumarin
Acetyl-YVAD-AMC
N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-methylcoumarin
MFCD00171369
Ac-Tyr-Val-Ala-Asp-MCA
Ac-YVAD-AMC
Ac-Tyr-Val-Ala-Asp-AMC
AMC120
AC-YVAD-AMC

物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
1127.3±65.0 °C at 760 mmHg

[ 分子式 ]:
C₃₃H₃₉N₅O₁₀

[ 分子量 ]:
665.690

[ 闪点 ]:
635.6±34.3 °C

[ 精确质量 ]:
665.269714

[ PSA ]:
233.24000

[ LogP ]:
2.58

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.605

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
DMSO: 10 mM The solution is stable in the dark at −20 °C for more than 1 month if no water is present.

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

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文献

A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes.

Nature 356 , 768, (1992)

Interleukin-1 beta (IL-1 beta)-converting enzyme cleaves the IL-1 beta precursor to mature IL-1 beta, an important mediator of inflammation. The identification of the enzyme as a unique cysteine prote...

Processing/activation of CPP32-like proteases is involved in transforming growth factor beta1-induced apoptosis in rat hepatocytes.

Hepatology 25 , 1516, (1997)

Apoptosis induced in rat hepatocytes by transforming growth factor beta1 (TGF-beta1) was accompanied by the activation of interleukin-1beta converting enzyme (ICE)-like proteases. Cell lysates were is...

Partial purification and characterization of two distinct types of caspases from human epidermis.

J. Invest. Dermatol. 111 , 367-372, (1998)

Recent observations demonstrated that interleukin-1beta converting enzyme family proteases, now referred to as caspase family, play central roles in apoptosis, or programmed cell death. In this study,...

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