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3-氨基丙醇

3-氨基丙醇用途

【用途一】
用于合成环磷酰胺、心可定等药物，也可用于合成DL-泛醇
【用途二】
用于有机合成
【用途三】
可用有机合成的中间体。用于合成环磷酰胺、心可定等药物。

3-氨基丙醇名称

[ CAS 号 ]:
156-87-6

[ 中文名 ]:
3-氨基-1-丙醇

[ 英文名 ]:
3-Aminopropan-1-ol

[中文别名 ]:

[英文别名 ]:

3-Amino-1-propanol
3-Aminopropyl alcohol
1-Propanol, 3-amino-
γ-Aminopropanol
EINECS 205-864-4
3-Amino-1-propanol,3-Aminopropyl alcohol
Propanolamine
β-Alaninol
4-Aminothiophenol
MFCD00008223

3-氨基丙醇物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
187.5±0.0 °C at 760 mmHg

[ 熔点 ]:
10-12 °C(lit.)

[ 分子式 ]:
C₃H₉NO

[ 分子量 ]:
75.110

[ 闪点 ]:
79.4±0.0 °C

[ 精确质量 ]:
75.068413

[ PSA ]:
46.25000

[ LogP ]:
-1.12

[ 外观性状 ]:
透明至淡黄色液体

[ 蒸汽密度 ]:
2.59 (vs air)

[ 蒸汽压 ]:
0.2±0.7 mmHg at 25°C

[ 折射率 ]:
1.443

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (吸湿)

[ 水溶解性 ]:
miscible

3-氨基丙醇MSDS

详细MSDS(安全技术说明书)

3-氨基丙醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UA5600000

CHEMICAL NAME :: 1-Propanol, 3-amino-

CAS REGISTRY NUMBER :: 156-87-6

BEILSTEIN REFERENCE NO. :: 0741855

LAST UPDATED :: 199701

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C3-H9-N-O

MOLECULAR WEIGHT :: 75.13

WISWESSER LINE NOTATION :: Z3Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,683,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,683,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2830 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1202 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 97,1117,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1250 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 5700 ug/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 4,141,1971

3-氨基丙醇安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive;

[ 风险声明 (欧洲) ]:
R20/21/22;R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 2735 8/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
UA5600000

[ 包装等级 ]:
II

[ 危险类别 ]:
8

[ 海关编码 ]:
2922199090

3-氨基丙醇上下游产品

3-氨基丙醇上游产品

3-氨基丙醇下游产品

3-氨基丙醇制备

1.由β-羟基丙腈化催化加氢而得。将β-羟基丙腈、阮尼镍和乙醇、氨加入高压釜中，通氢气至2.94MPa，于100-120℃保持氢气压力，至不吸氢后继续保温2h。反应结束后降温，过滤回收阮尼镍，将滤液减压蒸馏，收集90-92℃/2.0kPa馏分而得，含量95%以上，收率接近70%。

3-氨基丙醇海关

[ 海关编码 ]: 2922199090

[ 中文概述 ]:
2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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