Collismycin A

Collismycin A用途

Collismycin A is a bacterial metabolite with antibacterial, antiproliferative, and neuroprotective properties. It is active against a variety of bacteria and fungi. It inhibits proliferation of A549 lung, HCT116 colon, HeLa cervical cancer cells, and NIH373 fibroblasts but not MDA-MD-231 breast cancer cells. Collismycin A forms a complex with Fe(II) and Fe(III) at a 2:1 ratio, and the addition of iron ions inhibits the antiproliferative effect of collismycin A on HeLa cells, an effect that does not occur with the addition of zinc, manganese, copper, or magnesium ions. Collismycin A (1 μM) prevents apoptosis in the brain region of zebrafish larvae by 44% in a model of neuronal cell death induced by all-trans retinoic acid.

Collismycin A名称

[ CAS 号 ]:
158792-24-6

[ 英文名 ]:
Collismycin A

[英文别名 ]:

Collismycin A

Collismycin A物理化学性质

[ 密度 ]:
1.27g/cm3

[ 沸点 ]:
381.2ºC at 760 mmHg

[ 分子式 ]:
C₁₃H₁₃N₃O₂S

[ 分子量 ]:
275.32600

[ 闪点 ]:
184.3ºC

[ 精确质量 ]:
275.07300

[ PSA ]:
92.90000

[ LogP ]:
2.68220

[ 蒸汽压 ]:
5.16E-06mmHg at 25°C

[ 折射率 ]:
1.624

Collismycin A安全信息

[ 海关编码 ]:
2933399090

Collismycin A海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%