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脱氢枞酸； 脱氢松香酸

脱氢枞酸； 脱氢松香酸用途

Dehydroabietic acid 具有抗病毒活性。

脱氢枞酸； 脱氢松香酸名称

[ CAS 号 ]:
1740-19-8

[ 中文名 ]:
脱氢枞酸

[ 英文名 ]:
dehydroabietic acid

[中文别名 ]:

[英文别名 ]:

脱氢枞酸； 脱氢松香酸生物活性

[ 描述 ]:

Dehydroabietic acid 具有抗病毒活性。

[ 相关类别 ]:

研究领域 >> 感染
信号通路 >> 其他 >> 其他

[参考文献]

[1]. Fonseca T, et al. Synthesis and antiviral evaluation of benzimidazoles, quinoxalines and indoles from dehydroabietic acid. Bioorg Med Chem. 2004 Jan 2;12(1):103-12.

脱氢枞酸； 脱氢松香酸物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
425.1±34.0 °C at 760 mmHg

[ 熔点 ]:
174-176ºC

[ 分子式 ]:
C20H28O2

[ 分子量 ]:
300.435

[ 闪点 ]:
202.5±20.3 °C

[ 精确质量 ]:
300.208923

[ PSA ]:
37.30000

[ LogP ]:
6.35

[ 外观性状 ]:
NA

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.540

[ 储存条件 ]:
?20°C

脱氢枞酸； 脱氢松香酸MSDS

详细MSDS(安全技术说明书)

脱氢枞酸； 脱氢松香酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TP8710000
CHEMICAL NAME :
Podocarpa-8,11,13-trien-15-oic acid, 13-isopropyl-
CAS REGISTRY NUMBER :
1740-19-8
BEILSTEIN REFERENCE NO. :
2059290
LAST UPDATED :
199710
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C20-H28-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1710 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - ataxia
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 18,42,1977 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8400 mg/kg/28D-C
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical - Metabolism (Intermediary) - Plasma proteins not involving coagulation
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 18,42,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2653 No. of Facilities: 1630 (estimated) No. of Industries: 16 No. of Occupations: 20 No. of Employees: 13811 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2653 No. of Facilities: 394 (estimated) No. of Industries: 8 No. of Occupations: 12 No. of Employees: 14625 (estimated) No. of Female Employees: 4688 (estimated)

脱氢枞酸； 脱氢松香酸安全信息

[ 符号 ]:

GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H410

[ 警示性声明 ]:
P273-P301 + P310-P501

[ 危害码 (欧洲) ]:
T,N

[ 风险声明 (欧洲) ]:
25-50

[ 安全声明 (欧洲) ]:
45-61

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

脱氢枞酸； 脱氢松香酸上下游产品

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脱氢枞酸； 脱氢松香酸文献

Development of ultrasonic-assisted closed in-syringe extraction and derivatization for the determination of labile abietic acid and dehydroabietic acid in cosmetics.

J. Chromatogr. A. 1371 , 20-9, (2014)

Two resin acids, abietic acid (AA) and dehydroabietic acid (DHAA), in cosmetics may cause allergy or toxicoderma, but remain inaccurately investigated due to their lability. In this work, an accurate,...

Disproportionated rosin dehydroabietic acid in neoprene surgical gloves.

Dermatitis 21(3) , 157-9, (2010)

Allergic contact dermatitis (ACD) is a well-recognized immune-mediated disease often associated with the use of vulcanization accelerator-containing latex and nitrile gloves. Potential contact allerge...

Synthesis and antibacterial evaluation of New N-acylhydrazone derivatives from dehydroabietic acid.

Molecules 17(4) , 4634-50, (2012)

A series of new N-acylhydrazone derivatives were synthesized in good yields through the reactions of dehydroabietic acid hydrazide with a variety of substituted arylaldehydes. The structures of the sy...


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