叔丁基二甲基氯硅烷

叔丁基二甲基氯硅烷用途

【用途一】
用于合成前列腺素，某些抗生素，降血脂药洛伐他汀和辛伐他汀的辅助原料
【用途二】
用作医药中间体及用于有机合成，在有机合成中作为羟基保护剂
【用途三】
硅烷化剂。有机合成中作为羟基保护剂,衍生化试剂用于分析和制备。保护叔醇类。与醇类反应形成硅醚。测定胆固醇衍生物的构象。合成前列腺素，某些抗生素、降血脂药洛弗斯汀(Lovastatin)和新弗斯汀(Simvastatin)的辅助原料。

叔丁基二甲基氯硅烷名称

[ CAS 号 ]:
18162-48-6

[ 中文名 ]:
叔丁基二甲基氯硅烷

[ 英文名 ]:
tert-Butyldimethylsilyl chloride

[中文别名 ]:

[英文别名 ]:

Silane, chloro-tert-butyldimethyl-
tert-Butyldimethylsilyl chloride
t-butyldimethylchlorosilane
Silane, chloro(1,1-dimethylethyl)dimethyl-
TBDMSCl
TBUME2SI-CL
tbdmschloride
tert-butyldimethylsilylchloride
EINECS 242-042-4
tert-Butyldimethylsilyl chloride

叔丁基二甲基氯硅烷物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
125.0±0.0 °C at 760 mmHg

[ 熔点 ]:
86-89 °C

[ 分子式 ]:
C₆H₁₅ClSi

[ 分子量 ]:
150.722

[ 闪点 ]:
22.8±0.0 °C

[ 精确质量 ]:
150.063156

[ LogP ]:
3.40

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
15.0±0.2 mmHg at 25°C

[ 折射率 ]:
1.411

[ 储存条件 ]:
Store at 5°C

[ 水溶解性 ]:
可溶于：苯,甲苯,二氯甲烷,乙醚

叔丁基二甲基氯硅烷MSDS

叔丁基二甲基氯硅烷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VV2000000

CHEMICAL NAME :: Silane, t-butylchlorodimethyl-

CAS REGISTRY NUMBER :: 18162-48-6

BEILSTEIN REFERENCE NO. :: 0505999

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C6-H15-Cl-Si

MOLECULAR WEIGHT :: 150.75

WISWESSER LINE NOTATION :: G-SI-1&1&X1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Immunological Including Allergic - decreased immune response

REFERENCE :: StoGD# Personal Communication from G.D. Stoner, Dept. of Community Medicine, School of Medicine, Univ. of California, La Jolla, CA 92037, May 25, 1975 Volume(issue)/page/year: 27MAY1975

叔丁基二甲基氯硅烷安全信息

[ 符号 ]:

GHS02, GHS05, GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H304-H314-H336-H361d-H373

[ 补充危害声明 ]:
May form explosive peroxides.

[ 警示性声明 ]:
P210-P261-P280-P301 + P310-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R10;R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S46-S62-S45-S25-S16-S28-S27-S33-S29-S53

[ 危险品运输编码 ]:
UN 2925 4.1/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
VV2000000

[ 包装等级 ]:
III

[ 危险类别 ]:
4.1

[ 海关编码 ]:
29310095

叔丁基二甲基氯硅烷合成路线

叔丁基二甲基氯硅烷上下游产品

叔丁基二甲基氯硅烷上游产品

叔丁基二甲基氯硅烷下游产品

叔丁基二甲基氯硅烷制备

1. 制二甲基二氯硅烷将170克80目的硅与30克氯化亚铜一道研磨成粉，松松地装入一根3大40厘米的硬质玻璃管中。管的一端熔接一支水冷凝器，另一端塞上塞子。塞子上安装一根短的气体导入管和插入物料之中的温度计。冷凝器则依次与一支接收器、冷到一80℃的捕集器和一支干燥管相串联。将反应管置于电炉中加热，并缓缓通入氯甲烷气体(7克/时)。当温度达到265℃时，氯化亚铜被还原，铜则沉积在硅粉上。继续加热到300-305℃，并通入氧甲烷气流70小时。合并捕集器和接收器中的粗产物，将其慢慢温热，以便蒸出未反应的氯甲烷。用高效分馏柱蒸馏，得36%左右的二甲基二氯硅烷。

2. 制叔丁基二甲基氧硅烷将1摩尔/升的二甲基二氯硅烷(1.15当量)戊烷溶液冷却到0℃，在氮气存在和搅拌下，滴加叔丁基锉(1.0当量)戊烷溶液。将温度继续维持在0℃并搅抨1.5小时之后，在25℃搅拌继续48小时。蒸馏，收集沸点125℃/733mm的馏分，得产率为70%的纯品。静置固化。

叔丁基二甲基氯硅烷海关

[ 海关编码 ]: 2931900090

[ 中文概述 ]:
2931900090. 其他有机-无机化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:6.5%. 普通关税:30.0%

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

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