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5a-雄甾烷-3a,17b-二醇

5a-雄甾烷-3a,17b-二醇用途

【用途一】
用作合成性激素的原料

5a-雄甾烷-3a,17b-二醇名称

[ CAS 号 ]:
1852-53-5

[ 中文名 ]:
5a-雄甾烷-3a,17b-二醇

[ 英文名 ]:
5a-Androstane-3a,17b-diol

[中文别名 ]:

[英文别名 ]:

5a-androstane-3a,17b-diol
5A-ANDROSTAN-3A,17SS-DIOL
5alpha-androstane-3alpha,17beta-diol
dihydroandrosterone
DIHYDROANDROSTANEDIOL
[3H]-Hombreol
Hombreol
Etiocholane-3alpha,17beta-diol
EINECS 217-447-4
Androstane-3alpha,17beta-diol

5a-雄甾烷-3a,17b-二醇物理化学性质

[ 密度 ]:
1.09g/cm3

[ 沸点 ]:
415ºC at 760 mmHg

[ 分子式 ]:
C₁₉H₃₂O₂

[ 分子量 ]:
292.45600

[ 精确质量 ]:
292.24000

[ PSA ]:
40.46000

[ LogP ]:
3.75090

[ 蒸汽压 ]:
1.27E-08mmHg at 25°C

[ 折射率 ]:
1.546

[ 储存条件 ]:
室温

5a-雄甾烷-3a,17b-二醇MSDS

5a-雄甾烷-3a,17b-二醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BV8044310

CHEMICAL NAME :: 5-alpha-Androstane-3-alpha,17-beta-diol

CAS REGISTRY NUMBER :: 1852-53-5

BEILSTEIN REFERENCE NO. :: 2694353

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C19-H32-O2

MOLECULAR WEIGHT :: 292.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 48 mg/kg

SEX/DURATION :: male 6 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: JSTBBK Journal of Steroid Biochemistry. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 0BW, UK) V.1- 1969- Volume(issue)/page/year: 18,397,1983

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 8 mg/kg

SEX/DURATION :: female 13-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 99,1490,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 40 mg/kg

SEX/DURATION :: female 13-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - skin and skin appendages

REFERENCE :: ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 99,1490,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 200 ug/kg

SEX/DURATION :: male 20 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 89,69,1990

5a-雄甾烷-3a,17b-二醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
BV8044310

5a-雄甾烷-3a,17b-二醇合成路线

5a-雄甾烷-3a,17b-二醇上下游产品

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5a-雄甾烷-3a,17b-二醇文献

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

An updated steroid benchmark set and its application in the discovery of novel nanomolar ligands of sex hormone-binding globulin.

J. Med. Chem. 51 , 2047-56, (2008)

A benchmark data set of steroids with known affinity for sex hormone-binding globulin (SHBG) has been widely used to validate popular molecular field-based QSAR techniques. We have expanded the data s...

Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies.

J. Med. Chem. 51 , 1831-41, (2008)

TGR5, a metabotropic receptor that is G-protein-coupled to the induction of adenylate cyclase, has been recognized as the molecular link connecting bile acids to the control of energy and glucose home...

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