4,4'-(1-acetyl-2-oxoindolin-3-ylidene)diphenyl di(acetate)

名称

[ CAS 号 ]:
18869-73-3

[ 英文名 ]:
4,4'-(1-acetyl-2-oxoindolin-3-ylidene)diphenyl di(acetate)

[英文别名 ]:

Laxagen
Phenisatin
Isatex
Laxagetten
EINECS 242-638-4
3,3-bis-(4-acetoxy-phenyl)-1-acetyl-indolin-2-one
Triacetyldiphenolisatin
Neo-Hollaxans
Trialax
Dissilax-Zaepfchen

物理化学性质

[ 密度 ]:
1.306g/cm3

[ 沸点 ]:
623.6ºC at 760 mmHg

[ 分子式 ]:
C₂₆H₂₁NO₆

[ 分子量 ]:
443.44800

[ 闪点 ]:
331ºC

[ 精确质量 ]:
443.13700

[ PSA ]:
89.98000

[ LogP ]:
3.82970

[ 蒸汽压 ]:
1.79E-15mmHg at 25°C

[ 折射率 ]:
1.613

[ 储存条件 ]:
库房通风低温干燥

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM3250000

CHEMICAL NAME :: 2H-Indol-2-one, 1,3-dihydro-1-acetyl-3,3-bis(4-(acetyloxy)phenyl)-

CAS REGISTRY NUMBER :: 18869-73-3

BEILSTEIN REFERENCE NO. :: 0365442

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C26-H21-N-O6

MOLECULAR WEIGHT :: 443.48

WISWESSER LINE NOTATION :: T56 BNV DHJ BV1 DR DOV1& DOV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 42,468,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 42,468,1953 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 90 mg/kg/30D-C

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 42,468,1953

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 5460 mg/kg/1Y-C

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 42,468,1953

安全信息

[ 海关编码 ]:
2933790090

合成路线

详细合成路线

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海关

[ 海关编码 ]: 2933790090

[ 中文概述 ]:
2933790090 其他内酰胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:9.0% 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%