沙甲胺醇

沙甲胺醇用途

Salmeterol is a long-acting beta2-adrenergic receptor agonist drug used in the maintenance and prevention of asthma symptoms and maintenance of chronic obstructive pulmonary disease (COPD) symptoms. Symptoms include shortness of breath, wheezing, coughing and chest tightness. Salmeterol is also used to prevent breathing difficulties during exercise (exercise induced bronchospasm). It is marketed as Serevent in the US.

沙甲胺醇名称

[ CAS 号 ]:
18910-65-1

[ 中文名 ]:
沙甲胺醇

[ 英文名 ]:
Salmefamol

[英文别名 ]:

Salmefamolum [INN-Latin]
AHR 3929
AH-3923
Salmefamol
EINECS 242-662-5

沙甲胺醇物理化学性质

[ 密度 ]:
1.2g/cm3

[ 沸点 ]:
553.4ºC at 760mmHg

[ 分子式 ]:
C₁₉H₂₅NO₄

[ 分子量 ]:
331.40600

[ 闪点 ]:
288.5ºC

[ 精确质量 ]:
331.17800

[ PSA ]:
81.95000

[ LogP ]:
2.53820

[ 蒸汽压 ]:
4.43E-13mmHg at 25°C

[ 折射率 ]:
1.598

沙甲胺醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ6438000

CHEMICAL NAME :: 1,3-Benzenedimethanol, 4-hydroxy-alpha(sup 1)-(((2-(4-methoxyphenyl)-1-methylethyl)amino) methyl)-

CAS REGISTRY NUMBER :: 18910-65-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H25-N-O4

MOLECULAR WEIGHT :: 331.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 51,627,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 51,627,1975