(R)-(-)-NIGULDIPINE HYDROCHLORIDE

(R)-(-)-NIGULDIPINE HYDROCHLORIDE名称

[ CAS 号 ]:
189624-85-9

[ 英文名 ]:
(R)-(-)-NIGULDIPINE HYDROCHLORIDE

[英文别名 ]:

(R)-(-)-NIGULDIPINE HYDROCHLORIDE物理化学性质

[ 沸点 ]:
780.5ºC at 760 mmHg

[ 分子式 ]:
C41H44Cl2N4O6

[ 分子量 ]:
759.71700

[ 闪点 ]:
425.8ºC

[ 精确质量 ]:
758.26400

[ PSA ]:
116.93000

[ LogP ]:
9.31740

[ 蒸汽压 ]:
2.62E-24mmHg at 25°C

(R)-(-)-NIGULDIPINE HYDROCHLORIDE毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
US7201200
CHEMICAL NAME :
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(4-(4- (diphenylmethyl)-1-piperazinyl)phenyl)ethyl methyl ester, dihydrochloride, (S)-(+)-
CAS REGISTRY NUMBER :
189624-85-9
LAST UPDATED :
199806
DATA ITEMS CITED :
2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>12 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - conjunctive irritation Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 25(Suppl 3),S745,1997 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
14850 ug/kg/9D-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), diffuse Blood - normocytic anemia Related to Chronic Data - death
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 25(Suppl 3),S793,1997

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相关化合物

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标题：189624-85-9_(R)-(-)-NIGULDIPINE HYDROCHLORIDECAS号:189624-85-9_(R)-(-)-NIGULDIPINE HYDROCHLORIDE【结构式 性质 英文】 - 化源网 地址：https://www.chemsrc.com/amp/cas/189624-85-9_36802.html