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(S)-10-羟基喜树碱

(S)-10-羟基喜树碱用途

(S)-10-Hydroxycamptothecin 是临床治疗肝癌的有效试剂。

(S)-10-羟基喜树碱名称

[ CAS 号 ]:
19685-09-7

[ 中文名 ]:
10-羟基喜树碱

[ 英文名 ]:
(S)-10-Hydroxycamptothecin

[中文别名 ]:

[英文别名 ]:

10-Hydroxycamptothecin
Hydroxycamptothecine
10-Hydroxy camptothecin
10-OH-camptothecin
10-hydroxy-CPT
Camptothecin,hydroxy
MFCD00189425
10-Hydroxycamptochecin
Camptothecin, 10-hydroxy
10-hydroxy-Camptothecin

(S)-10-羟基喜树碱生物活性

[ 描述 ]:

(S)-10-Hydroxycamptothecin 是临床治疗肝癌的有效试剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

天然产物 >> 生物碱

研究领域 >> 癌症

[参考文献]

[1]. Min Liu, et al. Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance . Journal of Drug Targeting.

[2]. Min Liu, et al. Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance. J Drug Target, Early Online: 1–8

[相关活性小分子]

(S)-10-羟基喜树碱物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
820.7±65.0 °C at 760 mmHg

[ 熔点 ]:
265-270°C

[ 分子式 ]:
C₂₀H₁₆N₂O₅

[ 分子量 ]:
364.351

[ 闪点 ]:
450.1±34.3 °C

[ 精确质量 ]:
364.105927

[ PSA ]:
101.65000

[ LogP ]:
1.32

[ 外观性状 ]:
固体;White to Yellow to Orange powder to crystal

[ 蒸汽压 ]:
0.0±3.1 mmHg at 25°C

[ 折射率 ]:
1.777

[ 储存条件 ]:
-20°C Freezer

(S)-10-羟基喜树碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ0491700

CAS REGISTRY NUMBER :: 19685-09-7

LAST UPDATED :: 198305

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C20-H16-N2-O5.H2-O

MOLECULAR WEIGHT :: 382.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 104 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Cells - not otherwise specified

DOSE/DURATION :: 100 ug/L

REFERENCE :: YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year: 21,492,1986

(S)-10-羟基喜树碱安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2934999090

(S)-10-羟基喜树碱合成路线

详细合成路线

(S)-10-羟基喜树碱上下游产品

(S)-10-羟基喜树碱上游产品

(S)-10-羟基喜树碱下游产品

(S)-10-羟基喜树碱海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%