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6-甲氧基-1,2,3,4-四氢-9-H-吡啶[3,4-b]吲哚

名称

[ CAS 号 ]:
20315-68-8

[ 中文名 ]:
2,3,4,9-四氢-6-甲氧基-1H-吡咯[3,4-B]吲哚

[ 英文名 ]:
6-METHOXY-1,2,3,4-TETRAHYDRO-BETA-CARBOLINE

[中文别名 ]:

6-甲氧基-1,2,3,4-四氢-β-咔啉

[英文别名 ]:

MFCD00012071
6-methoxytryptoline
6-MeOthbc

物理化学性质

[ 密度 ]:
1.198 g/cm3

[ 沸点 ]:
388.6ºC at 760 mmHg

[ 熔点 ]:
219-222ºC(lit.)

[ 分子式 ]:
C₁₂H₁₄N₂O

[ 分子量 ]:
202.25200

[ 闪点 ]:
188.8ºC

[ 精确质量 ]:
202.11100

[ PSA ]:
37.05000

[ LogP ]:
2.15100

[ 外观性状 ]:
黄褐色光敏固体

[ 蒸汽压 ]:
3.03E-06mmHg at 25°C

[ 折射率 ]:
1.639

[ 储存条件 ]:
室温，干燥，避光

MSDS

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV0725000

CHEMICAL NAME :: 1H-Pyrido(3,4-b)indole, 2,3,4,9-tetrahydro-6-methoxy-

CAS REGISTRY NUMBER :: 20315-68-8

BEILSTEIN REFERENCE NO. :: 0172873

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H14-N2-O

MOLECULAR WEIGHT :: 202.28

WISWESSER LINE NOTATION :: T B656 EM HMT&&J LO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 415 mg/kg/5W-C

TOXIC EFFECTS :: Endocrine - changes in pituitary weight Related to Chronic Data - changes in ovarian weight Related to Chronic Data - changes in uterine weight

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,47,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 440 mg/kg/5W-I

TOXIC EFFECTS :: Vascular - regional or general arteriolar constriction Endocrine - changes in spleen weight Related to Chronic Data - changes in uterine weight

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 28,47,1978

安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
UV0725000

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文献

Melatonin and structurally-related compounds protect synaptosomal membranes from free radical damage.

Int. J. Mol. Sci. 11 , 312-28, (2010)

Since biological membranes are composed of lipids and proteins we tested the in vitro antioxidant properties of several indoleamines from the tryptophan metabolic pathway in the pineal gland against o...

In vivo hepatic oxidative stress because of carbon tetrachloride toxicity: protection by melatonin and pinoline.

J. Pineal Res. 49(1) , 78-85, (2010)

The protective in vivo effects of melatonin or pinoline on carbon tetrachloride (CCl(4))-induced oxidative damage were investigated in liver of rats and compared to rats injected only with CCl(4) (5 m...

Pinoline may be used as a probe for CYP2D6 activity.

Drug Metab. Dispos. 37(3) , 443-6, (2009)

Pinoline, 6-methoxy-1,2,3,4-tetrahydro-beta-carboline, is a serotonin analog that selectively inhibits the activity of monoamine oxidase-A and shows antidepressant activity. Our previous study using a...

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