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10,11-Dehydrocurvularin

10,11-Dehydrocurvularin用途

10,11-Dehydrocurvularin 是一种常见的真菌毒素和抗生素。10,11-Dehydrocurvularin 是热休克反应的强激活剂。10,11-Dehydrocurvularin 抑制 TGF-β 信号通路。抗肿瘤活性

10,11-Dehydrocurvularin名称

[ CAS 号 ]:
21178-57-4

[ 中文名 ]:
10,11-dehydro Curvularin

[ 英文名 ]:
10,11-Dehydrocurvularin

[英文别名 ]:

trans-dehydrocurvularin
E-dehydrocurvularin
10,11-dehydrocurvularin
8-dehydrocurvularin
Dehydrocurvularin
AmbotzLS-1091

10,11-Dehydrocurvularin生物活性

[ 描述 ]:

10,11-Dehydrocurvularin 是一种常见的真菌毒素和抗生素。10,11-Dehydrocurvularin 是热休克反应的强激活剂。10,11-Dehydrocurvularin 抑制 TGF-β 信号通路。抗肿瘤活性

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 干细胞及 Wnt 通路 >> TGF-β/Smad蛋白

信号通路 >> 代谢酶/蛋白酶 >> HSP

信号通路 >> TGF-beta/Smad 信号通路 >> TGF-β/Smad蛋白

研究领域 >> 感染

信号通路 >> 细胞周期/DNA损伤 >> HSP

[参考文献]

[1]. Xu Y, et al. Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus. Appl Environ Microbiol. 2013 Mar;79(6):2038-47.

[2]. Cochrane RV, et al. Comparison of 10,11-Dehydrocurvularin Polyketide Synthases from Alternaria cinerariae and Aspergillus terreus Highlights Key Structural Motifs. Chembiochem. 2015 Nov;16(17):2479-83.

10,11-Dehydrocurvularin物理化学性质

[ 密度 ]:
1.225 g/cm3

[ 沸点 ]:
576.3ºC at 760 mm

[ 分子式 ]:
C₁₆H₁₈O₅

[ 分子量 ]:
290.31100

[ 闪点 ]:
216.7ºC

[ 精确质量 ]:
290.11500

[ PSA ]:
83.83000

[ LogP ]:
2.49480

[ 蒸汽压 ]:
7.02E-14mmHg at 25°C

[ 折射率 ]:
1.555

[ 储存条件 ]:
-20°C，密闭，干燥

10,11-Dehydrocurvularin安全信息

[ 海关编码 ]:
2932999099

10,11-Dehydrocurvularin海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%