1-(2-phenoxyphenoxy)-3-(propan-2-ylamino)propan-2-ol,hydrochloride

名称

[ CAS 号 ]:
21299-86-5

[ 英文名 ]:
1-(2-phenoxyphenoxy)-3-(propan-2-ylamino)propan-2-ol,hydrochloride

[英文别名 ]:

Ph-QA 33

物理化学性质

[ 沸点 ]:
453.4ºC at 760 mmHg

[ 分子式 ]:
C₁₈H₂₄ClNO₃

[ 分子量 ]:
337.84100

[ 闪点 ]:
228ºC

[ 精确质量 ]:
337.14400

[ PSA ]:
50.72000

[ LogP ]:
4.40950

[ 蒸汽压 ]:
5.18E-09mmHg at 25°C

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UB7560000

CHEMICAL NAME :: 2-Propanol, 1-(isopropylamino)-3-(o-phenoxyphenoxy)-, hydrochloride, (+-)-

CAS REGISTRY NUMBER :: 21299-86-5

LAST UPDATED :: 199509

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C18-H23-N-O3.Cl-H

MOLECULAR WEIGHT :: 337.88

WISWESSER LINE NOTATION :: 1Y1&M1YQ1OR BOR &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 810 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 26,343,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 27,453,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 36 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 26,343,1968

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: >50 mg/kg

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Behavioral - food intake (animal)

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 26,343,1968