6H-Purine-6-thione,2-amino-9-(2-deoxy-a-D-erythro-pentofuranosyl)-1,9-dihydro-

名称

[ CAS 号 ]:
2133-81-5

[ 英文名 ]:
6H-Purine-6-thione,2-amino-9-(2-deoxy-a-D-erythro-pentofuranosyl)-1,9-dihydro-

物理化学性质

[ 密度 ]:
2.02g/cm3

[ 沸点 ]:
709.1ºC at 760 mmHg

[ 分子式 ]:
C₁₀H₁₃N₅O₃S

[ 分子量 ]:
283.30700

[ 闪点 ]:
382.6ºC

[ 精确质量 ]:
283.07400

[ PSA ]:
154.30000

[ LogP ]:
0.29300

[ 蒸汽压 ]:
4.22E-21mmHg at 25°C

[ 折射率 ]:
1.93

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UP0745000

CHEMICAL NAME :: 9H-Purine-6(1H)-thione, 2-amino-9-(2-deoxy-alpha-D-erythro-pentofuranosyl)-

CAS REGISTRY NUMBER :: 2133-81-5

LAST UPDATED :: 199703

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C10-H13-N5-O3-S

MOLECULAR WEIGHT :: 283.34

WISWESSER LINE NOTATION :: T56 BN DN FYM INJ FUS HZ B- ET5OTJ B1Q CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1 gm/kg/5D-I

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1500 mg/kg/33D-I

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Blood - leukopenia Blood - thrombocytopenia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 3 gm/kg/5D-I

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Blood - agranulocytosis Skin and Appendages - dermatitis, other (after systemic exposure)

MUTATION DATA

TYPE OF TEST :: Host-mediated assay

TEST SYSTEM :: Rodent - mouse Cells - not otherwise specified

DOSE/DURATION :: 100 umol/kg

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 35,1103,1975