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25-羟基维生素 D2

25-羟基维生素 D2用途

Ercalcidiol 是一种 vitamin D₂ 代谢物，作为 vitamin D 营养状态的指标。

25-羟基维生素 D2名称

[ CAS 号 ]:
21343-40-8

[ 中文名 ]:
25-羟基维生素 D2

[ 英文名 ]:
25-Hydroxycalciferol

[中文别名 ]:

[英文别名 ]:

25-Hydroxy Vitamin D2
9,10-Secoergosta-5,7,10(19),22-tetraene-3b,25-diol
9,10-Secoergosta-5,7,10(19),22-tetraene-3β,25-diol
EINECS 200-578-6
25-Hydroxyvitamin D2
25-Hydroxyvitamin D 2
25-Hydroxyergocalciferol
25-Hydroxyergocalciferol 25-Hydroxycalciferol
MFCD02683431
25-Hydroxycalciferol

25-羟基维生素 D2生物活性

[ 描述 ]:

Ercalcidiol 是一种 vitamin D2 代谢物,作为 vitamin D 营养状态的指标。

[ 相关类别 ]:

信号通路 >> 维生素 D 相关 >> VD/VDR

研究领域 >> 代谢疾病

天然产物 >> 类固醇

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

Ercalcidiol(25(OH)D2)和25(OH)D3之间的区别对于监测维生素D治疗非常重要,因为维生素D2是主要的处方形式。 Ercalcidiol的半衰期短于25(OH)D3的半衰期,并且它与维生素D结合蛋白的结合较差,使其效力较低,因此需要以比维生素D3高得多的剂量给药。一些目前使用的检测方法检测Ercalcidiol的能力降低,当试图用维生素D2监测治疗时,这会导致危险的过量给药[2]。

[参考文献]

[1]. Li L, et al. Performance evaluation of two immunoassays for 25-hydroxyvitamin D. J Clin Biochem Nutr. 2016 May;58(3):186-92.

[2]. Newman MS, et al. A liquid chromatography/tandem mass spectrometry method for determination of 25-hydroxy vitamin D2 and 25-hydroxy vitamin D3 in dried blood spots: a potential adjunct to diabetes and cardiometabolic risk screening. J Diabetes Sci Technol

[相关活性小分子]

25-羟基维生素 D2物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
542.3±38.0 °C at 760 mmHg

[ 熔点 ]:
45-51ºC

[ 分子式 ]:
C₂₈H₄₄O₂

[ 分子量 ]:
412.648

[ 闪点 ]:
225.9±21.4 °C

[ 精确质量 ]:
412.334137

[ PSA ]:
40.46000

[ LogP ]:
7.56

[ 蒸汽压 ]:
0.0±3.3 mmHg at 25°C

[ 折射率 ]:
1.543

[ 储存条件 ]:
−20°C

25-羟基维生素 D2MSDS

详细MSDS(安全技术说明书)

25-羟基维生素 D2安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H319

[ 警示性声明 ]:
P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+,F

[ 风险声明 (欧洲) ]:
24/25-26-48/25-11

[ 安全声明 (欧洲) ]:
28-36/37-45-16-7

[ 危险品运输编码 ]:
UN2811 6

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25-羟基维生素 D2文献

Improved analysis of vitamin D metabolites in plasma using liquid chromatography tandem mass spectrometry, and its application to cardiovascular research.

Biomed. Chromatogr. 28(6) , 913-7, (2014)

The accurate and specific measurement of vitamin D is increasingly important for determining the role of vitamin D in the pathogenesis of disease. Liquid chromatography coupled to tandem mass spectrom...

Common variants in CYP2R1 and GC genes are both determinants of serum 25-hydroxyvitamin D concentrations after UVB irradiation and after consumption of vitamin D₃-fortified bread and milk during winter in Denmark.

Am. J. Clin. Nutr. 101(1) , 218-27, (2015)

Little is known about how the genetic variation in vitamin D modulating genes influences ultraviolet (UV)B-induced 25-hydroxyvitamin D [25(OH)D] concentrations. In the Food with vitamin D (VitmaD) stu...

Prospective association of 25-hydroxyvitamin d3 and d2 with childhood lung function, asthma, wheezing, and flexural dermatitis.

Epidemiology 24(2) , 310-9, (2013)

Higher serum total 25-hydroxyvitamin D (25(OH)D) concentrations have been associated with better lung function and lower risk of allergic disease. 25(OH)D3 constitutes the majority of total 25(OH)D an...

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