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杆菌肽 A

杆菌肽 A名称

[ CAS 号 ]:
22601-59-8

[ 中文名 ]:
杆菌肽 A

[ 英文名 ]:
Bacitracin A1 (9CI)

[英文别名 ]:

baccharinoid B12
Solu-Tracin 50

杆菌肽 A物理化学性质

[ 密度 ]:
1.43 g/cm3

[ 沸点 ]:
1755.5ºC at 760 mmHg

[ 分子式 ]:
C₆₆H₁₀₃N₁₇O₁₆S

[ 分子量 ]:
1422.69000

[ 闪点 ]:
1015.5ºC

[ 精确质量 ]:
1421.75000

[ PSA ]:
556.17000

[ LogP ]:
3.72410

[ 储存条件 ]:
2-8°C

杆菌肽 A毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CP0350000

CHEMICAL NAME :: Bacitracin A

CAS REGISTRY NUMBER :: 22601-59-8

LAST UPDATED :: 199512

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C66-H103-N17-O16-S

MOLECULAR WEIGHT :: 1422.92

WISWESSER LINE NOTATION :: T5N CS AUTJ BYZY2 EVMY1Y&&VMY2VQVMYY2&&VM-WT-23-VM DVM GVM JVM MVM QVMTJ C3Z FY2 I1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 158 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity)

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 6,417,1951 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 474 mg/kg/3D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 6,417,1951

杆菌肽 A安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

杆菌肽 A文献

Validation of a quantitative HPLC method for bacitracin and bacitracin zinc using EDTA as a mobile-phase modifier.

J. Pharm. Biomed. Anal. 70 , 619-23, (2012)

Any product marketed in the United States and labeled bacitracin must comply with the tests, procedures, and acceptance criteria in the relevant monograph published in the US Pharmacopeia (USP). The t...

Dereplicating nonribosomal peptides using an informatic search algorithm for natural products (iSNAP) discovery.

Proc. Natl. Acad. Sci. U. S. A. 109(47) , 19196-201, (2012)

Nonribosomal peptides are highly sought after for their therapeutic applications. As with other natural products, dereplication of known compounds and focused discovery of new agents within this class...

Affinity capillary electrophoresis study of the linkage existing between proton and zinc ion binding to bacitracin A1.

Electrophoresis 24(5) , 801-7, (2003)

Measurements by capillary electrophoresis (CE) of bacitracin A(1) effective mobility at different pH values permitted to estimate the five acidic dissociation constants and the Stokes radii at differe...

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