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|S|-(-)-1-Boc-2-吡咯烷甲腈

|S|-(-)-1-Boc-2-吡咯烷甲腈名称

[ CAS 号 ]:
228244-04-0

[ 中文名 ]:
(S)-1-N-Boc-2-吡咯烷甲腈

[ 英文名 ]:
(S)-tert-Butyl 2-cyanopyrrolidine-1-carboxylate

[中文别名 ]:

[英文别名 ]:

(s)-1-n-boc-2-cyanopyrrolidine
S-(-)-1-Boc-2-pyrrolidinecarbonitrile
MFCD01861225
N-tert-butyloxycarbonyl proline nitrile
(S)-tert-Butyl 2-cyanopyrrolidine-1-carboxylate

|S|-(-)-1-Boc-2-吡咯烷甲腈物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
307.9±35.0 °C at 760 mmHg

[ 熔点 ]:
33-36ºC

[ 分子式 ]:
C₁₀H₁₆N₂O₂

[ 分子量 ]:
196.246

[ 闪点 ]:
140.0±25.9 °C

[ 精确质量 ]:
196.121185

[ PSA ]:
53.33000

[ LogP ]:
0.40

[ 外观性状 ]:
固体;White to Orange to Green powder to lump

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.489

[ 储存条件 ]:
0-10°C

[ 水溶解性 ]:
可溶于：甲醇

|S|-(-)-1-Boc-2-吡咯烷甲腈MSDS

|S|-(-)-1-Boc-2-吡咯烷甲腈安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
26-36/37/39

[ 危险品运输编码 ]:
UN 3439

[ 海关编码 ]:
2933990090

|S|-(-)-1-Boc-2-吡咯烷甲腈合成路线

|S|-(-)-1-Boc-2-吡咯烷甲腈上下游产品

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|S|-(-)-1-Boc-2-吡咯烷甲腈海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

|S|-(-)-1-Boc-2-吡咯烷甲腈文献

New prolyl oligopeptidase inhibitors developed from dicarboxylic acid bis(l-prolyl-pyrrolidine) amides.

J. Med. Chem. 46 , 4543, (2003)

Isophthalic acid bis(l-prolyl-pyrrolidine) amide is a very potent prolyl oligopeptidase inhibitor, but it has a log P value of -0.2, which is very low for a compound targeted to the brain. Therefore, ...

Constrained peptidomimetics reveal detailed geometric requirements of covalent prolyl oligopeptidase inhibitors.

J. Med. Chem. 52 , 6672-84, (2009)

Prolyl oligopeptidases cleave peptides on the carboxy side of internal proline residues and their inhibition has potential in the treatment of human brain disorders. Using our docking program fitted, ...

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