雌二醇双[4-[二(2-氯乙基)氨基]苯乙酸]酯

雌二醇双[4-[二(2-氯乙基)氨基]苯乙酸]酯名称

[ CAS 号 ]:
22966-79-6

[ 中文名 ]:
雌二醇双[4-[二(2-氯乙基)氨基]苯乙酸]酯

[ 英文名 ]:
Estradiol bis[4-[bis(2-chloroethyl)amino]benzeneacetate]

[中文别名 ]:

[英文别名 ]:

Estradiol mustard
Oestradiol mustard

雌二醇双[4-[二(2-氯乙基)氨基]苯乙酸]酯物理化学性质

[ 密度 ]:
1.3

[ 沸点 ]:
850.8ºC at 760mmHg

[ 熔点 ]:
40-65ºC (freeze dried)

[ 分子式 ]:
C₄₂H₅₀Cl₄N₂O₄

[ 分子量 ]:
788.66900

[ 闪点 ]:
468.3ºC

[ 精确质量 ]:
786.25200

[ PSA ]:
59.08000

[ LogP ]:
9.41330

[ 蒸汽压 ]:
3.43E-28mmHg at 25°C

[ 折射率 ]:
1.625

雌二醇双[4-[二(2-氯乙基)氨基]苯乙酸]酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KG7300000

CHEMICAL NAME :: Estra-1,3,5(10)-triene-3,17-beta-diol, bis(p-(bis(2-chloroethylamino)phenyl)acetate)

CAS REGISTRY NUMBER :: 22966-79-6

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C42-H50-Cl4-N2-O4

MOLECULAR WEIGHT :: 788.74

WISWESSER LINE NOTATION :: L E5 B666TTT&J E1 FOV1R DN2G2G& OOV1R DN2G2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 560 mg/kg/14D-I

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - changes in potassium

REFERENCE :: CCYPBY Cancer Chemotherapy Reports, Part 3. (Washington, DC) V.1-6, 1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 4,121,1973 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2340 mg/kg/52W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - lymphoma, including Hodgkin's disease

REFERENCE :: NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*. Volume(issue)/page/year: NCI-TR-59,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 480 mg/kg/8W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 33,3069,1973

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4680 mg/kg/1Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Blood - lymphoma, including Hodgkin's disease

REFERENCE :: NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*. Volume(issue)/page/year: NCI-TR-59,1978 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 9,217,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 9,217,1975 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987