炔丙菊酯

炔丙菊酯用途

【用途一】
具有强烈的触杀作用，击倒和杀死性能是富右旋丙烯菊酯的四倍，主要用于制作蚊香、电热蚊香和液体蚊香
【用途二】
用于防治蚊子、苍蝇等卫生害虫。
【用途三】
富右旋丙炔菊酯产品性状与丙炔菊酯相同，具有强烈触杀作用，击倒和杀死性能是富右旋反式烯丙菊酯的4倍，并对蟑螂有突出的驱赶作用。主要用于加工蚊香、电热蚊香、液体蚊香和喷雾剂防治家蝇、蚊虫、虱、蟑螂等家庭害虫，推荐使用量如下：（以有效成份计）蚊香：含本品0.05% 电热蚊香：含本品10mg/片，控制电加热器中心温度125-135℃;液体蚊香：含本品0.66%，配加适量稳定剂;缓释剂; 气雾剂：本品0.05 - 0.2%，配加适量致死剂，增效剂，乳化剂。

炔丙菊酯名称

[ CAS 号 ]:
23031-36-9

[ 中文名 ]:
炔丙菊酯

[ 英文名 ]:
Prallethrin

[中文别名 ]:

[英文别名 ]:

protopamiodide
2-hydroxyiminomethyl-1-methylpyridinium iodide
1-methyl-2-hydroxyiminomethylpyridinium iodide
pralidoximemethiodide
PRALIDOXIMELODIDE
PRALIDOXIME IODIDE
MFCD01632766
pyridin-2-aldoxin
p-2-am
2-PAM

炔丙菊酯物理化学性质

[ 密度 ]:
1.08 g/cm3

[ 沸点 ]:
389.8ºC at 760 mmHg

[ 分子式 ]:
C₁₉H₂₄O₃

[ 分子量 ]:
300.39200

[ 闪点 ]:
167.9ºC

[ 精确质量 ]:
300.17300

[ PSA ]:
43.37000

[ LogP ]:
3.44920

[ 外观性状 ]:
固体

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

炔丙菊酯MSDS

详细MSDS(安全技术说明书)

炔丙菊酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GZ1725300

CHEMICAL NAME :: Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(2-methylpropenyl)-, ester with 4-hydroxy-3- methyl-2-(2-propynyl)-2-cyclopenten-1-one, trans-(+-)-

CAS REGISTRY NUMBER :: 23031-36-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C19-H24-O3

MOLECULAR WEIGHT :: 300.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 460 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 20,228,1989

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >848 ug/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 26,364,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C130,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 580 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 20,228,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 190 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 20,228,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 615 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 20,228,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 589 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 20,228,1989

炔丙菊酯安全信息

[ 符号 ]:

GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H331-H410

[ 警示性声明 ]:
P261-P273-P311-P501

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T,N

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S45-S60-S61

[ 危险品运输编码 ]:
UN2811 6.1/PG 2

[ 海关编码 ]:
2916209027

炔丙菊酯制备

1.炔酮菊醇的制备在乙醇钠和无水乙醇存在下，乙酰乙酸乙酯与炔丙基苯磺酸酯搅拌反应8h，再回流1h，制得2-炔丙基-3-氧代丁酸乙酯，产率85.3%。将上步产物滴加到10%Na2CO3溶液中，同时蒸出产物与水的共沸物，生成5-氧代-1-己炔，收率63.8%。将Mg\CH3OH和碘加热回流，蒸出甲醇，加入二甲基甲酰胺（DMF），通CO2至饱和，加热蒸除余下的甲醇至馏出温度140℃，蒸馏时仍通CO2，最后再通1h CO2制得MMC（甲基镁碳酸酯）-DMF溶液。在MMC-DMF溶液中加入5-氧代-1-己炔，搅拌升温至110℃以上反应2h，蒸出DMF,加盐酸和水，至固体溶解，乙醚萃取，加KOH溶液，得25%3-氧代-6-庚炔酸钾溶液。
调节上述溶液至pH值8，升温至35℃，滴加丙酮醛，维持pH值8反应16h，冷却，用食盐饱和反应液，乙醚萃取，得3-羟基-8-壬炔-2，5-二酮，收率41.6%～46.8%。
将3-羟基-8-壬炔-2，5-二酮的乙醚溶液滴加10%NaOH，2.5h滴完，保温-8～10℃，然后在-8～-5℃继续反应3h，用浓盐酸调至中性，用食盐饱和，乙醚萃取，得黄色液体炔酮菊醇，产率59.9%。
上述路线是Schechter路线的改进，文献报道Schechter合成路线如下：

炔酮菊醇也可通过呋喃衍生物来制备。鉴于炔丙基卤化物与镁反应可制得格氏试剂，通常需加汞盐，为避免环境污染，可用锌盐代替汞盐。进行连续格利雅反应中，炔丙基氯化物与炔丙基溴化物合用，可使反应十分稳定。然后进行糠醛转位反应和异构化反应。转位反应在酸性条件下进行，异构化反应在碱性条件下进行。

炔酮菊酯的合成 4-羟基-3-甲基-2-炔丙基环戊烯酮与菊酰氯反应，合成炔酮菊酯（菊酰氯的合成与一般拟除虫菊酰氯相同）。

炔丙菊酯海关

[ 海关编码 ]: 2916209027

炔丙菊酯文献

Evaluation of a new formulation of adulticide, DUET, against West Nile virus vector mosquitoes.

J. Am. Mosq. Control Assoc. 26(2) , 219-22, (2010)

DUET was evaluated against field-collected mosquito populations in St. John's County, FL, under laboratory and field conditions. Ten serial dilutions ranging from 22 to 2.2E-08 microg/ml of the produc...

Efficacy of Duet dual-action adulticide against caged Aedes albopictus with the use of an ultra-low volume cold aerosol sprayer.

J. Am. Mosq. Control Assoc. 28(4) , 338-40, (2012)

Duet was field evaluated against caged Aedes albopictus, with the use of a truck-mounted ultra-low volume (ULV) cold aerosol sprayer at the rate of 90.6 ml/ha. Cages were placed in 3 rows stationed 30...

Behavioral responses of two dengue virus vectors, Aedes aegypti and Aedes albopictus (Diptera: Culicidae), to DUET and its components.

J. Med. Entomol. 50(5) , 1059-70, (2013)

Ultralow volume droplets of DUET, prallethrin, and sumithrin at a sublethal dose were applied to unfed (nonbloodfed) and bloodfed female Aedes aegypti L. and Aedes albopictus (Skuse) in a wind tunnel....

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