溴替尼持

溴替尼持用途

该品为抗肝片吸虫药，特别对肝片吸虫幼虫具有良好的驱虫效果。对急性感染肝片吸虫的4-8周龄幼虫减虫率为72-100%；对8-10周龄幼虫为97-100%。以亚急性肝片吸虫病6-10周龄幼虫灭虫率为96%以上；10周龄幼虫减虫率几乎达100%。对慢性肝片吸虫病10周龄幼虫和成虫减虫率为89-93%。对严重感染的病畜以10.5mg/kg剂量，经药二次，间隔30d，减虫率可达995。对暴发性的严重感染病畜，为彻底清除幼虫起见，必须在30天后重复治疗一次，经治疗的羊乳量平均可增加19%，对乳质无影响。对枝腔吸虫的效果，按2.5-10mg/kg给药，减虫率可达95%。该品毒副作用小，耐受良好。绵羊口服LD50为40-45mg/kg。治疗指数为4-7。由于该药毒性低，故孕畜、新分娩畜、泌乳畜和羔羊均可使用。

溴替尼持名称

[ CAS 号 ]:
23233-88-7

[ 中文名 ]:
溴替尼持

[ 英文名 ]:
brotianide

[中文别名 ]:

[英文别名 ]:

Brotianida [INN-Spanish]
BAY-VA 4059
Brotianide
Brotianidum [INN-Latin]
EINECS 245-505-9
Dirian
FB a 4059

溴替尼持物理化学性质

[ 密度 ]:
1.795g/cm3

[ 沸点 ]:
514.1ºC at 760mmHg

[ 熔点 ]:
181°C

[ 分子式 ]:
C₁₅H₁₀Br₂ClNO₂S

[ 分子量 ]:
463.57100

[ 闪点 ]:
264.7ºC

[ 精确质量 ]:
460.84900

[ PSA ]:
70.42000

[ LogP ]:
5.65090

[ 蒸汽压 ]:
1.11E-10mmHg at 25°C

[ 折射率 ]:
1.699

[ 储存条件 ]:
库房通风低温干燥,与食品原料类分开存放

溴替尼持毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VN8230000

CHEMICAL NAME :: Salicylanilide, 3,4'-dibromo-5-chlorothio-, acetate (ester)

CAS REGISTRY NUMBER :: 23233-88-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C15-H10-Br2-Cl-N-O2-S

MOLECULAR WEIGHT :: 463.59

WISWESSER LINE NOTATION :: QVR DG BE FYUS&MR DE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 33,273,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - chromodacryorrhea

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 33,273,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 184 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 33,273,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - nausea or vomiting

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 33,273,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 33,273,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973

溴替尼持安全信息

[ 海关编码 ]:
2930909090

溴替尼持制备

以5-氯水杨酸为原料,在三氯化磷存在下,与对溴苯胺缩合成5-氯-N-(4′-溴苯基)苯甲酰胺,经溴化、氯化亚砜
氯化,然后与硫代乙酸(或硫化钠)置换、酰化即得溴硫酰胺。

溴替尼持海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%