普立地芬
普立地芬名称
[ CAS 号 ]:
23239-78-3
[ 中文名 ]:
普立地芬
[ 英文名 ]:
Pyrrolidine,3-(diphenylmethylene)-1-ethyl-, hydrochloride (1:1)
[英文别名 ]:
- Pridefine hydrochloride (USAN)
- PRIDEFINE HYDROCHLORIDE
- AHR-1118
- Pridefine
- Pridefine HCl
普立地芬物理化学性质
[ 沸点 ]:
396.1ºC at 760mmHg
[ 分子式 ]:
C19H22ClN
[ 分子量 ]:
299.83800
[ 闪点 ]:
173ºC
[ 精确质量 ]:
299.14400
[ PSA ]:
3.24000
[ LogP ]:
4.95400
[ 蒸汽压 ]:
1.75E-06mmHg at 25°C
普立地芬毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UY1050000
- CHEMICAL NAME :
- Pyrrolidine, 3-diphenylmethylene-1-ethyl-, hydrochloride
- CAS REGISTRY NUMBER :
- 23239-78-3
- LAST UPDATED :
- 199012
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C19-H21-N.Cl-H
- MOLECULAR WEIGHT :
- 299.87
- WISWESSER LINE NOTATION :
- T5N CYTJ A2 CUYR&R &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 166 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,199,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 90 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,199,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 39 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,199,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 144 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,199,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 167 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,199,1972
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