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纳布啡盐酸盐水合物

纳布啡盐酸盐水合物名称

[ CAS 号 ]:
23277-43-2

[ 中文名 ]:
纳布啡盐酸盐水合物

[ 英文名 ]:
Nalbuphine Hydrochloride

[英文别名 ]:

Nalbuphine hydrochloride
Nalbuphine hydrochloride hydrate

纳布啡盐酸盐水合物物理化学性质

[ 沸点 ]:
566.6ºC at 760 mmHg

[ 熔点 ]:
230.5ºC

[ 分子式 ]:
C₂₁H₂₈ClNO₄

[ 分子量 ]:
393.90400

[ 闪点 ]:
296.5ºC

[ 精确质量 ]:
393.17100

[ PSA ]:
73.16000

[ LogP ]:
2.44720

[ 外观性状 ]:
白色至近乎于白色固体

[ 蒸汽压 ]:
1.12E-13mmHg at 25°C

[ 储存条件 ]:
?20°C

[ 水溶解性 ]:
H2O: soluble

纳布啡盐酸盐水合物MSDS

纳布啡盐酸盐水合物毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QD3181000

CHEMICAL NAME :: Morphinan-3,6-alpha,14-triol, 17-(cyclobutylmethyl)-4,5-alpha-epoxy-, hydrochloride

CAS REGISTRY NUMBER :: 23277-43-2

LAST UPDATED :: 199504

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C21-H27-N-O4.Cl-H

MOLECULAR WEIGHT :: 393.95

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 800 ug/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - acute pulmonary edema

REFERENCE :: CHETBF Chest. (American College of Chest Physicians, 911 Busse Hwy, Park Ridge, IL 60068) V.57- 1970- Volume(issue)/page/year: 90,773,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 16,51,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 16,51,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 16,51,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5314 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 628 (estimated) No. of Female Employees: 314 (estimated)

纳布啡盐酸盐水合物安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311-H330-H370

[ 警示性声明 ]:
P210-P260-P280-P284-P301 + P310-P310

[ 危害码 (欧洲) ]:
T+: Very toxic;

[ 风险声明 (欧洲) ]:
26/27/28

[ 安全声明 (欧洲) ]:
22-36/37/39-45

[ 危险品运输编码 ]:
UN 1544

[ RTECS号 ]:
QD3181000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

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