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2-甲氧基-1,4-萘并醌

2-甲氧基-1,4-萘并醌用途

Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) 是从凤仙花和 Swertia calycina 中分离出的,具有有效的抗真菌和抗菌活性。

2-甲氧基-1,4-萘并醌名称

[ CAS 号 ]:
2348-82-5

[ 中文名 ]:
2-甲氧基-1,4-萘醌

[ 英文名 ]:
Lawsone methyl ether

[中文别名 ]:

2-甲氧基-1,4-萘并醌

[英文别名 ]:

2-Methoxy-p-naphthoquinone
1,4-Naphthalenedione,2-methoxy
2-methoxy-1,4-naphthalenequinone
2-methoxynaphthalene-1,4-dione
2-Methoxy-[1,4]naphthoquinone
2-methoxyl-1,4-naphthoquinone
2-Methoxynaphthoquinone
1,4-NAPHTHOQUINONE,2-METHOXY
MFCD00019539
2-Methoxy-1,4-naphthalenedione

2-甲氧基-1,4-萘并醌生物活性

[ 描述 ]:

Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) 是从凤仙花和 Swertia calycina 中分离出的,具有有效的抗真菌和抗菌活性。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

信号通路 >> 抗感染 >> 细菌

[体外研究]

Lawsone甲醚(2-甲氧基-1,4-萘醌)对念珠菌的最小抑菌浓度和最小杀菌浓度均为1.25 lg/ml[1]。

[参考文献]

[1]. Sritrairat N, et al. Antifungal activity of lawsone methyl ether in comparison with chlorhexidine. J Oral Pathol Med. 2011 Jan;40(1):90-6.

2-甲氧基-1,4-萘并醌物理化学性质

[ 密度 ]:
1.28g/cm3

[ 沸点 ]:
339.8ºC at 760mmHg

[ 熔点 ]:
184-187ºC(lit.)

[ 分子式 ]:
C₁₁H₈O₃

[ 分子量 ]:
188.17900

[ 闪点 ]:
152.7ºC

[ 精确质量 ]:
188.04700

[ PSA ]:
43.37000

[ LogP ]:
1.59590

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
8.98E-05mmHg at 25°C

[ 折射率 ]:
1.589

[ 储存条件 ]:
-20℃

2-甲氧基-1,4-萘并醌MSDS

2-甲氧基-1,4-萘并醌毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL8960000

CHEMICAL NAME :: 1,4-Naphthoquinone, 2-methoxy-

CAS REGISTRY NUMBER :: 2348-82-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C11-H8-O3

MOLECULAR WEIGHT :: 188.19

WISWESSER LINE NOTATION :: L66 BV EVJ CO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,570,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983

2-甲氧基-1,4-萘并醌安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
S26;S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
QL8960000

[ 海关编码 ]:
2914690090

2-甲氧基-1,4-萘并醌合成路线

2-甲氧基-1,4-萘并醌上下游产品

2-甲氧基-1,4-萘并醌上游产品

2-甲氧基-1,4-萘并醌下游产品

2-甲氧基-1,4-萘并醌海关

[ 海关编码 ]: 2914690090

[ 中文概述 ]:
2914690090 其他醌. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ Summary ]:
2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

2-甲氧基-1,4-萘并醌文献

2-Methoxy-1,4-naphthoquinone (MNQ) induces apoptosis of A549 lung adenocarcinoma cells via oxidation-triggered JNK and p38 MAPK signaling pathways.

Life Sci. 135 , 158-64, (2015)

The compound 2-methoxy-1,4-naphthoquinone (MNQ) was previously shown to be cytotoxic against several cancer cell lines, but its mode of action is poorly understood. In this study, we aimed to explore ...

Anti-gastric adenocarcinoma activity of 2-Methoxy-1,4-naphthoquinone, an anti-Helicobacter pylori compound from Impatiens balsamina L.

Fitoterapia 83(8) , 1336-44, (2012)

2-Methoxy-1,4-naphthoquinone (MeONQ) from Impatiens balsamina L. exhibited strong anti-H. pylori activity in our previous study. In this study, we investigated the cytotoxicity of MeONQ against gastri...

Effects of the compounds 2-methoxynaphthoquinone, 2-propoxynaphthoquinone, and 2-isopropoxynaphthoquinone on ecdysone 20-monooxygenase activity.

Arch. Insect Biochem. Physiol. 66(1) , 45-52, (2007)

The effects of the natural compound 2-methoxy-1,4-naphthoquinone, isolated from the leaves of Impatiens glandulifera and the synthetic compounds 2-propoxy-1,4-naphthoquinone and 2-isopropoxy-1,4-napht...

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