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10-姜酚

10-姜酚用途

10-Gingerol 是姜根脂的一种主要刺激性成分,具有抗炎、抗氧化和抗增殖活性。10-Gingerol 能抑制 MDA-MB-231 肿瘤细胞的增殖,其 IC50 值为 12.1 μM。

10-姜酚名称

[ CAS 号 ]:
23513-15-7

[ 中文名 ]:
[10]-姜酚

[ 英文名 ]:
10-Gingerol

[中文别名 ]:

[英文别名 ]:

<10>-Gingerol
10-Gingerol

10-姜酚生物活性

[ 描述 ]:

10-Gingerol 是姜根脂的一种主要刺激性成分,具有抗炎、抗氧化和抗增殖活性。10-Gingerol 能抑制 MDA-MB-231 肿瘤细胞的增殖,其 IC50 值为 12.1 μM。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Dugasani S, et al. Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. J Ethnopharmacol. 2010 Feb 3;127(2):515-20.

[2]. Almada da Silva J, et al. Purification and differential biological effects of ginger-derived substances on normal and tumor cell lines. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Aug 15;903:157-62.

10-姜酚物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
499.7±35.0 °C at 760 mmHg

[ 熔点 ]:
45 - 46 °C

[ 分子式 ]:
C₂₁H₃₄O₄

[ 分子量 ]:
350.492

[ 闪点 ]:
166.4±19.4 °C

[ 精确质量 ]:
350.245697

[ PSA ]:
66.76000

[ LogP ]:
4.61

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.513

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
methanol: soluble5mg/mL, clear, colorless

10-姜酚MSDS

10-姜酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XB8720000

CHEMICAL NAME :: 3-Tetradecanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (S)-

CAS REGISTRY NUMBER :: 23513-15-7

LAST UPDATED :: 199503

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H34-O4

MOLECULAR WEIGHT :: 350.55

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 25,231,1990

10-姜酚安全信息

[ 危害声明 ]:
H413

[ 危害码 (欧洲) ]:
T+

[ 风险声明 (欧洲) ]:
53

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2914509090

10-姜酚合成路线

10-姜酚海关

[ 海关编码 ]: 2914509090

[ 中文概述 ]:
2914509090 含其他含氧基的酮. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

10-姜酚文献

Regioselective glucuronidation of gingerols by human liver microsomes and expressed UDP-glucuronosyltransferase enzymes: reaction kinetics and activity correlation analyses for UGT1A9 and UGT2B7.

J. Pharm. Pharmacol. 67(4) , 583-96, (2015)

To determine the reaction kinetics for regioselective glucuronidation of gingerols (i.e. 6-, 8- and 10-gingerol) by human liver microsomes and expressed UDP-glucuronosyltransferase (UGT) enzymes, and ...

Identification of serotonin 5-HT1A receptor partial agonists in ginger.

Bioorg. Med. Chem. 18 , 3345-51, (2010)

Animal studies suggest that ginger (Zingiber officinale Roscoe) reduces anxiety. In this study, bioactivity-guided fractionation of a ginger extract identified nine compounds that interact with the hu...

Antiallergic potential on RBL-2H3 cells of some phenolic constituents of Zingiber officinale (ginger).

J. Nat. Prod. 72 , 950-3, (2009)

In the present study on five pure phenolic compounds (1-5) isolated from the rhizomes of Zingiber officinale (ginger) and investigated for their antiallergic potency, rat basophilic leukemia (RBL-2H3)...

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