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甲基硫菌灵

甲基硫菌灵用途

Thiophanate-Methyl 是一种内吸性杀菌剂。

甲基硫菌灵名称

[ CAS 号 ]:
23564-05-8

[ 中文名 ]:
甲基硫菌灵

[ 英文名 ]:
Thiophanate-methyl

[中文别名 ]:

[英文别名 ]:

Thiophanate-methyl
Fungitox
Thiophanate, methyl ester
EINECS 245-740-7
Spot Kleen
Frumidor
1,2-bis(Methoxycarbonylthioueido) benzene
dimethyl 4,4’-(o-phenylene)bis(3-thioallophanate)
MFCD00055294
UNII:K4N81R84L8

甲基硫菌灵生物活性

[ 描述 ]:

Thiophanate-Methyl 是一种内吸性杀菌剂。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

[参考文献]

[1]. Sharma G, et al. Guar gum-crosslinked-Soya lecithin nanohydrogel sheets as effective adsorbent for the removal of thiophanate methyl fungicide. Int J Biol Macromol. 2018 Jul 15;114:295-305.

甲基硫菌灵物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
478.4ºC at 760 mmHg

[ 熔点 ]:
172°C

[ 分子式 ]:
C₁₂H₁₄N₄O₄S₂

[ 分子量 ]:
342.39

[ 精确质量 ]:
342.045654

[ PSA ]:
164.90000

[ LogP ]:
1.16

[ 外观性状 ]:
无色晶体,或白色或淡棕色粉末

[ 蒸汽压 ]:
2.58E-09mmHg at 25°C

[ 折射率 ]:
1.709

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, alkalies, copper salts.

[ 水溶解性 ]:
<0.1 g/100 mL at 20 ºC

甲基硫菌灵MSDS

详细MSDS(安全技术说明书)

甲基硫菌灵毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BA3675000

CHEMICAL NAME :: Allophanic acid, 4,4'-o-phenylenebis(3-thio-, dimethyl ester

CAS REGISTRY NUMBER :: 23564-05-8

LAST UPDATED :: 199806

DATA ITEMS CITED :: 29

MOLECULAR FORMULA :: C12-H14-N4-O4-S2

MOLECULAR WEIGHT :: 342.42

WISWESSER LINE NOTATION :: 1OVMYUS&MR BMYUS&MVO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6640 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - olfactory nerve change Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1700 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1140 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - olfactory nerve change Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3400 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - olfactory nerve change Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 790 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - olfactory nerve change Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2270 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3640 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 86 gm/kg/26W-C

TOXIC EFFECTS :: Blood - changes in spleen Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9100 mg/kg/13W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - body temperature increase Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 173 gm/kg/26W-C

TOXIC EFFECTS :: Blood - changes in other cell count (unspecified) Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 960 mg/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 15 gm/kg

SEX/DURATION :: female 1-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 300,15,1993 *** REVIEWS *** TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 32,151,1975 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 63,1,1976 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

甲基硫菌灵安全信息

[ 符号 ]:

GHS07, GHS08, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317-H332-H341-H410

[ 警示性声明 ]:
P261-P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R20;R43;R50/53;R68

[ 安全声明 (欧洲) ]:
36/37-46-60-61

[ 危险品运输编码 ]:
UN 3077

[ WGK德国 ]:
3

[ RTECS号 ]:
BA3675000

甲基硫菌灵制备

1.氯甲酸甲酯的制备：甲醇与光气于5～15℃合成氯甲酸甲酯，由于光气遇水易分解，因此要注意干燥，温度过高易生成副产物碳酸二甲酯。
2.异硫氰基甲酸甲酯的制备：以丙酮为溶剂，氯甲酸甲酯与硫氰化钠作用制得。要控制好反应温度，若温度过高，异硫氰酸酯易分解，温度较低不易发生异构化，一般以45～59℃为宜。注意在滴加氯甲酸甲酯时，温度过高，极易暴沸溢出，以38℃为宜。
3.甲基硫菌灵的合成邻苯二胺与异硫氰基甲酸甲酯于15～40℃加成制得甲基硫菌灵。严格控制原料配比为1：2。
生产过程中溶剂回收技术见《现代农药》，2003年第6期

甲基硫菌灵文献

Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): Identification of phenmedipham and amperozide as FAAH inhibitors

Bioorg. Med. Chem. Lett. 19 , 6793-6, (2009)

The screening of known medicinal agents against new biological targets has been shown to be a valuable approach for revealing new pharmacology of marketed compounds. Recently, carbamate, urea and keto...

New active drugs against liver stages of Plasmodium predicted by molecular topology.

Antimicrob. Agents Chemother. 52 , 1215-20, (2008)

We conducted a quantitative structure-activity relationship (QSAR) study based on a database of 127 compounds previously tested against the liver stage of Plasmodium yoelii in order to develop a model...

Biological monitoring of pesticide exposures in residents living near agricultural land.

BMC Public Health 11 , 856, (2011)

There is currently a lack of reliable information on the exposures of residents and bystanders to pesticides in the UK. Previous research has shown that the methods currently used for assessing pestic...

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