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Iperoxo

Iperoxo用途

对于M2和M4,EC50分别为2.12nM和8.47nM的极其有效的毒蕈碱受体激动剂；在Gi/Gs信号传导能力CHO-hM2细胞中显着超过ACh。

Iperoxo名称

[ CAS 号 ]:
247079-84-1

[ 中文名 ]:
4-[(4,5-二氢-3-异恶唑基)氧基]-N,N,N-三甲基 2-丁炔-1-碘化铵

[ 英文名 ]:
Iperoxo

[英文别名 ]:

MFCD26793886

Iperoxo生物活性

[ 描述 ]:

对于M2和M4,EC50分别为2.12nM和8.47nM的极其有效的毒蕈碱受体激动剂；在Gi/Gs信号传导能力CHO-hM2细胞中显着超过ACh。

[参考文献]

References 1. Schrage R, et al. Br J Pharmacol. 2013 May;169(2):357-70. 2. Kruse AC, et al. Nature. 2013 Dec 5;504(7478):101-6. 3. Croy CH, et al. Mol Pharmacol. 2014 Jul;86(1):106-15. View Related Products by Target mAChR

Iperoxo物理化学性质

[ 熔点 ]:
211.5 - 212.5 °C

[ 分子式 ]:
C₁₀H₁₇IN₂O₂

[ 分子量 ]:
324.159

[ 精确质量 ]:
324.033478

[ 外观性状 ]:
固体

[ 储存条件 ]:
2-8°C

Iperoxo安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 危险品运输编码 ]:
NONH for all modes of transport

Iperoxo文献

Bis(ammonio)alkane-type agonists of muscarinic acetylcholine receptors: synthesis, in vitro functional characterization, and in vivo evaluation of their analgesic activity.

Eur. J. Med. Chem. 75 , 222-32, (2014)

In this study, we synthesized and tested in vitro and in vivo two groups of bis(ammonio)alkane-type compounds, 6a-9a and 6b-9b, which incorporate the orthosteric muscarinic agonist iperoxo into a mole...

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