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格洛沙腙

格洛沙腙用途

Gloxazone是一种有效但有毒的无血浆药[1]。

格洛沙腙名称

[ CAS 号 ]:
2507-91-7

[ 中文名 ]:
格洛沙腙

[ 英文名 ]:
gloxazone

[英文别名 ]:

WR 9838
Gloxazon
2-Keto-3-aethoxy-butyraldehyd-bis-thiosemicarbazon
3-Aethoxy-2-keto-butyraldehyd-bis-thiosemicarbazon
GLOXAZONE
BW 356C61
KTS,pharmaceutical
KC 1331
KTS
3-Aethoxy-butan-1,2-dion-bis-thiosemicarbazon

格洛沙腙生物活性

[ 描述 ]:

Gloxazone是一种有效但有毒的无血浆药[1]。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[体内研究]

格列沙酮(5 mg/kg；静脉注射)对人工感染边缘Anaplama的阉牛有效[1]。格列沙酮(0.1-3 mg/kg/天；口服)引起大鼠肾乳头状坏死和肾毒性[1]。

[参考文献]

[1]. McHardy N, et al. Comparison of gloxazone, an effective but toxic anaplasmacide, with imidocarb dihydrochloride. Res Vet Sci. 1980 Sep;29(2):198-202.

格洛沙腙物理化学性质

[ 密度 ]:
1.41g/cm3

[ 沸点 ]:
419.7ºC at 760mmHg

[ 分子式 ]:
C₈H₁₆N₆OS₂

[ 分子量 ]:
276.38200

[ 闪点 ]:
207.6ºC

[ 精确质量 ]:
276.08300

[ PSA ]:
174.23000

[ LogP ]:
1.60200

[ 蒸汽压 ]:
2.97E-07mmHg at 25°C

[ 折射率 ]:
1.645

格洛沙腙毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ES2450000

CHEMICAL NAME :: Butyraldehyde, 3-ethoxy-2-oxo-, bis(thiosemicarbazone)

CAS REGISTRY NUMBER :: 2507-91-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C8-H16-N6-O-S2

MOLECULAR WEIGHT :: 276.42

WISWESSER LINE NOTATION :: SUYZMNUYY1&O2&1UNMYZUS

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >3200 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - sensory change involving peripheral nerve Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 440 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - sensory change involving peripheral nerve Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 195 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - sensory change involving peripheral nerve Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 182 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1600 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 475 mg/kg/5D-I

TOXIC EFFECTS :: Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 190 mg/kg/5D-I

TOXIC EFFECTS :: Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg/5D-I

TOXIC EFFECTS :: Behavioral - ataxia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 100 mg/kg/10D-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 90 mg/kg/30D-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 250 mg/kg/10D-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 300 mg/kg/10D-I

TOXIC EFFECTS :: Behavioral - coma Endocrine - hypoglycemia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 300 mg/kg/30D-I

TOXIC EFFECTS :: Endocrine - hypoglycemia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human HeLa cell

DOSE/DURATION :: 50 umol/l

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 92,427,1982

格洛沙腙安全信息

[ 海关编码 ]:
2930909090

格洛沙腙合成路线

详细合成路线

格洛沙腙上下游产品

格洛沙腙上游产品

格洛沙腙下游产品

格洛沙腙海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%