喜树碱钠

喜树碱钠用途

Sodium Camptothecin 是一种具有抗肿瘤活性的植物生物碱。Sodium Camptothecin 是一种可逆的 RNA 合成 (RNA synthesis) 抑制剂。Sodium Camptothecin 是一种有效的腺病毒复制抑制剂。Sodium Camptothecin 能抑制 (DNA synthesis),并在细胞内引起预先形成的病毒 DNA 断裂。

喜树碱钠名称

[ CAS 号 ]:
25387-67-1

[ 中文名 ]:
喜树碱钠盐

[ 英文名 ]:
20(S)-Camptothecin sodium salt

[英文别名 ]:

camptothecinsodium
camptothecin,sodiumsalt
Fda 1660
21,22-secocamptothecin-21-oicacid,monosodiumsalt
20(s)-camptothecinsodiumsalt
camptothecin Na
camptothecinesodium
CaMphotecin sodiuM

喜树碱钠生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成

[体外研究]

喜树碱钠(5μ米；10分钟)会严重抑制异质沉积的核RNA(HRNA)合成[1]。喜树碱钠还阻断了核糖体前体RNA加工的一个特定步骤,允许45S RNA转化为32S RNA,但抑制了32S RNA转化为28S RNA[1]。

[参考文献]

[1]. R S Wu, et al. Ribosome formation is blocked by camptothecin, a reversible inhibitor of RNA synthesis. Proc Natl Acad Sci U S A. 1971 Dec;68(12):3009-14.

[2]. M S Horwitz, et al. Camptothecin: mechanism of inhibition of adenovirus formation. Virology. 1972 Jun;48(3):690-8

喜树碱钠物理化学性质

[ 沸点 ]:
777.3ºC at 760 mmHg

[ 分子式 ]:
C₂₀H₁₇N₂NaO₅

[ 分子量 ]:
388.34900

[ 闪点 ]:
423.9ºC

[ 精确质量 ]:
388.10400

[ PSA ]:
115.48000

[ LogP ]:
0.26500

[ 蒸汽压 ]:
1.96E-25mmHg at 25°C

[ 储存条件 ]:
库房低温通风干燥,与食品原料分开存放

喜树碱钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EX1650000

CHEMICAL NAME :: Camptothecin, sodium salt

CAS REGISTRY NUMBER :: 25387-67-1

LAST UPDATED :: 199706

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C20-H18-N2-O5.Na

MOLECULAR WEIGHT :: 389.39

WISWESSER LINE NOTATION :: T F6 D6 C566 BN HVO LVN NHT&&&&J GQ G2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 2500 ug/kg/7D-I

TOXIC EFFECTS :: Blood - leukopenia Blood - thrombocytopenia Blood - changes in cell count (unspecified)

REFERENCE :: CCROBU Cancer Chemotherapy Reports, Part 1. (Washington, DC) V.52(6)-59, 1968-75. For publisher information, see CTRRDO. Volume(issue)/page/year: 56,515,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 27 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 9,1,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 151 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTKRDX Gan to Kagaku Ryoho. Cancer and Chemotherapy. (1-8-9 Yaesu, Chuo-ku, Tokyo 103, Japan) V.1- 1974- Volume(issue)/page/year: 14,850,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 57 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 9,1,1973

喜树碱钠安全信息

[ 危害码 (欧洲) ]:
T+

[ 海关编码 ]:
2942000000

喜树碱钠合成路线

详细合成路线

喜树碱钠上下游产品

喜树碱钠上游产品

喜树碱钠下游产品

喜树碱钠海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%