聚 L-赖氨酸盐酸盐

聚 L-赖氨酸盐酸盐用途

Poly-L-lysine hydrochloride 是一种非特异性的细胞附着因子,通过增强细胞膜负离子与培养基表面的静电相互作用,促进细胞对固体基质的粘附。Poly-L-lysine 是一种抗菌肽。Poly-L-lysine 低浓度促进相分离 (Liquid-liquid phase separation,LLPS),高浓度抑制相分离。

聚 L-赖氨酸盐酸盐名称

[ CAS 号 ]:
26124-78-7

[ 中文名 ]:
聚 L-赖氨酸盐酸盐

[ 英文名 ]:
Poly-L-lysine hydrochloride

[英文别名 ]:

MFCD00081870

聚 L-赖氨酸盐酸盐生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

研究领域 >> 炎症/免疫

信号通路 >> 抗感染 >> 细菌

[体外研究]

聚赖氨酸是一种与蛋白质形成复合物的食品级抗菌肽。这种复合物是靶向给药的潜在载体。用静电势模型描述了EPL的相互作用亲和力。建立了三维相界曲线,将络合分为纳米级和相分离两个阶段[2]。

[参考文献]

[1]. Archishman Ghosh, et al. Three archetypical classes of macromolecular regulators of protein liquid-liquid phase separation. Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19474-19483.

[2]. Liang Guo, et al. pH-induced structural transition during complexation and precipitation of sodium caseinate and ε-Poly-l-lysine. Int J Biol Macromol. 2020 Jul 1;154:644-653.

聚 L-赖氨酸盐酸盐物理化学性质

[ 分子式 ]:
(C₆H₁₄N₂O₂)x_.(HCl)x

[ 储存条件 ]:
−20°C

聚 L-赖氨酸盐酸盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

聚 L-赖氨酸盐酸盐文献

Tumor accumulation and antitumor efficacy of docetaxel-loaded core-shell-corona micelles with shell-specific redox-responsive cross-links

Biomaterials 33 , 1489-1499, (2012)

A robust core-shell-corona micelle bearing redox-responsive shell-specific cross-links was evaluated as a carrier of docetaxel (DTX) for cancer therapy. The polymer micelles of poly(ethylene glycol)- ...

Improving covalent cell encapsulation with temporarily reactive polyelectrolytes.

J. Mater. Sci. Mater. Med. 23(1) , 181-93, (2011)

Calcium alginate/poly-L-lysine beads were coated with either 50% hydrolyzed poly(methyl vinyl ether-alt-maleic anhydride) (PMM(50)), or with poly(vinyl dimethyl azlactone-co-methacrylic acid) (50:50, ...

Enhancement of airway gene transfer by DNA nanoparticles using a pH-responsive block copolymer of polyethylene glycol and poly-L-lysine.

Biomaterials 33(7) , 2361-71, (2011)

Highly compacted DNA nanoparticles, composed of single molecules of plasmid DNA compacted with block copolymers of polyethylene glycol and poly-L-lysine (PEG-CK(30)), have shown considerable promise i...

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