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异氟醚

异氟醚用途

用于各种手术全身、半身麻醉

异氟醚名称

[ CAS 号 ]:
26675-46-7

[ 中文名 ]:
异氟醚

[ 英文名 ]:
Isoflurane

[中文别名 ]:

[英文别名 ]:

异氟醚物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
48.5±0.0 °C at 760 mmHg

[ 分子式 ]:
C3H2ClF5O

[ 分子量 ]:
184.492

[ 闪点 ]:
-10.6±25.9 °C

[ 精确质量 ]:
183.971436

[ PSA ]:
9.23000

[ LogP ]:
2.33

[ 外观性状 ]:
异氟醚(26675-46-7)为无色透明液体。沸点48.5℃,25℃蒸气压44.0kPa。相对密度1.45,折光率(nD20)1.3002。略带刺激性醚样臭。

[ 蒸汽压 ]:
323.0±0.0 mmHg at 25°C

[ 折射率 ]:
1.301

[ 稳定性 ]:
Stable.

异氟醚MSDS

异氟醚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KN6799000
CHEMICAL NAME :
Ether, 1-chloro-2,2,2-trifluoroethyl difluoromethyl
CAS REGISTRY NUMBER :
26675-46-7
LAST UPDATED :
199612
DATA ITEMS CITED :
17
MOLECULAR FORMULA :
C3-H2-Cl-F5-O
MOLECULAR WEIGHT :
184.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4770 uL/kg
TOXIC EFFECTS :
Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3031,1987
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15300 ppm/3H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - excitement Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3031,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4280 uL/kg
TOXIC EFFECTS :
Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3031,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5080 uL/kg
TOXIC EFFECTS :
Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3031,1987
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
16800 ppm/3H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - excitement Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3031,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3030 uL/kg
TOXIC EFFECTS :
Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3031,1987 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
12000 ppm/3H/10W-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - death
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3037,1987
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
150 ppm/24H/5W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year: 42,408,1975
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1500 ppm/24H/5W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year: 42,408,1975 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
10500 ppm/6H
SEX/DURATION :
female 14-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year: 64,339,1986
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
4000 ppm/3H
SEX/DURATION :
female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3091,1987
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Inhalation
DOSE :
12000 ppm/3H
SEX/DURATION :
female 17-20 day(s) after conception lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - physical
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3109,1987
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
6000 ppm/4H
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 29(2),54A,1984 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,93,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3787 No. of Facilities: 1009 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 33152 (estimated) No. of Female Employees: 27151 (estimated)

异氟醚安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H336-H373

[ 警示性声明 ]:
P260

[ 靶器官 ]:
Cardio-vascular system, Central nervous system

[ 危害码 (欧洲) ]:
F,T

[ 风险声明 (欧洲) ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ 安全声明 (欧洲) ]:
S26-S36/37/39

[ 危险品运输编码 ]:
UN 3334

[ RTECS号 ]:
KN6799000

[ 海关编码 ]:
3004909030

异氟醚合成路线

异氟醚上下游产品

异氟醚制备

2,2,2-三氟乙醇用硫酸二甲酯进行甲基化,生成2,2,2-三氟乙基甲基醚。经光照氯化生成2,2,2-三氟乙基二氯甲基醚和1-氯-2,2,2-三氟乙基二氯甲基醚的混合物。


其中1-氯-2,2,2-三氟乙基二氯甲基醚直接氟化即可得异氟烷。


另一化合物,即2,2,2-三氟乙基二氯甲基醚经氟化后.再氯化也可得异氟烷。

异氟醚海关

[ 海关编码 ]: 2909199090

[ 中文概述 ]:
2909199090. 其他无环醚及其卤化衍生物(包括磺化,硝化或亚硝化衍生物). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

异氟醚文献

Imaging of a clinically relevant stroke model: glucose hypermetabolism revisited.

Stroke 46(3) , 835-42, (2015)

Ischemic stroke has been shown to cause hypermetabolism of glucose in the ischemic penumbra. Experimental and clinical data indicate that infarct-related systemic hyperglycemia is a potential therapeu...

Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPK.

EMBO J. 34(3) , 275-93, (2015)

Numerous extrinsic and intrinsic insults trigger the HSF1-mediated proteotoxic stress response (PSR), an ancient transcriptional program that is essential to proteostasis and survival under such condi...

Detailed characterization of a long-term rodent model of critical illness and recovery.

Crit. Care Med. 43(3) , e84-96, (2015)

To characterize a long-term model of recovery from critical illness, with particular emphasis on cardiorespiratory, metabolic, and muscle function.Randomized controlled animal study.University researc...


更多文献

相关化工产品/化学物质:

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推荐生产厂家/供应商:

公司名:上海化源世纪贸易有限公司

区域:上海市普陀区

价格:

联系人:徐经理

产品详情:异氟醚


公司名:上海吉至生化科技有限公司

区域:上海市奉贤区

价格:
¥758.0/25g ¥198.0/5g

联系人:刘佳

产品详情:异氟醚


公司名:上海源溪生物科技有限公司

区域:上海市浦东新区

价格:
¥需询单/1g

联系人:赖经理

产品详情:Isoflurane


公司名:上海脉铂医药科技有限公司

区域:上海市嘉定区

价格:
¥489.0/50mg ¥需询单/1g ¥需询单/1g ¥需询单/1g

联系人:李先生

产品详情:Isoflurane


公司名:上海阿拉丁生化科技股份有限公司

区域:上海市浦东新区

价格:
¥871.9/100g ¥311.9/25g ¥82.9/5g ¥43.9/1g

联系人:阿拉丁

产品详情:1-氯-2,2,2-三氟乙基二氟甲基醚


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异氟醚供应商


相关化合物

【异氟醚】化源网提供异氟醚CAS号26675-46-7,异氟醚MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询异氟醚上化源网,专业又轻松。>>电脑版:异氟醚

标题:异氟醚_MSDS_用途_密度_异氟醚CAS号【26675-46-7】_化源网 地址:https://www.chemsrc.com/amp/cas/26675-46-7_511753.html