异氟醚
异氟醚用途
异氟醚名称
[ CAS 号 ]:
26675-46-7
[ 中文名 ]:
异氟醚
[ 英文名 ]:
Isoflurane
[中文别名 ]:
[英文别名 ]:
- Isoflurano
- 1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether
- Forane
- Compd 469
- Isoflurane
- 1-Chlor-2,2,2-trifluorethyl-difluormethylether
- 2-(difluoromethoxy)-1,1,1-trifluoro-2-chloroethane
- 2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane
- MFCD00066609
- Forene
异氟醚物理化学性质
[ 密度 ]:
1.5±0.1 g/cm3
[ 沸点 ]:
48.5±0.0 °C at 760 mmHg
[ 分子式 ]:
C3H2ClF5O
[ 分子量 ]:
184.492
[ 闪点 ]:
-10.6±25.9 °C
[ 精确质量 ]:
183.971436
[ PSA ]:
9.23000
[ LogP ]:
2.33
[ 外观性状 ]:
异氟醚(26675-46-7)为无色透明液体。沸点48.5℃,25℃蒸气压44.0kPa。相对密度1.45,折光率(nD20)1.3002。略带刺激性醚样臭。
[ 蒸汽压 ]:
323.0±0.0 mmHg at 25°C
[ 折射率 ]:
1.301
[ 稳定性 ]:
Stable.
异氟醚MSDS
异氟醚毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KN6799000
- CHEMICAL NAME :
- Ether, 1-chloro-2,2,2-trifluoroethyl difluoromethyl
- CAS REGISTRY NUMBER :
- 26675-46-7
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 17
- MOLECULAR FORMULA :
- C3-H2-Cl-F5-O
- MOLECULAR WEIGHT :
- 184.50
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4770 uL/kg
- TOXIC EFFECTS :
- Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3031,1987
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 15300 ppm/3H
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - excitement Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3031,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4280 uL/kg
- TOXIC EFFECTS :
- Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3031,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5080 uL/kg
- TOXIC EFFECTS :
- Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3031,1987
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 16800 ppm/3H
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - excitement Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3031,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3030 uL/kg
- TOXIC EFFECTS :
- Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3031,1987 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 12000 ppm/3H/10W-I
- TOXIC EFFECTS :
- Endocrine - changes in adrenal weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - death
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3037,1987
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 150 ppm/24H/5W-C
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year: 42,408,1975
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1500 ppm/24H/5W-C
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year: 42,408,1975 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 10500 ppm/6H
- SEX/DURATION :
- female 14-16 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year: 64,339,1986
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 4000 ppm/3H
- SEX/DURATION :
- female 7-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3091,1987
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 12000 ppm/3H
- SEX/DURATION :
- female 17-20 day(s) after conception lactating female 21 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - physical
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,3109,1987
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 6000 ppm/4H
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system
- REFERENCE :
- TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 29(2),54A,1984 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,93,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3787 No. of Facilities: 1009 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 33152 (estimated) No. of Female Employees: 27151 (estimated)
异氟醚安全信息
[ 符号 ]:
GHS07, GHS08
[ 信号词 ]:
Warning
[ 危害声明 ]:
H336-H373
[ 警示性声明 ]:
P260
[ 靶器官 ]:
Cardio-vascular system, Central nervous system
[ 危害码 (欧洲) ]:
F,T
[ 风险声明 (欧洲) ]:
R36/37/38:Irritating to eyes, respiratory system and skin .
[ 安全声明 (欧洲) ]:
S26-S36/37/39
[ 危险品运输编码 ]:
UN 3334
[ RTECS号 ]:
KN6799000
[ 海关编码 ]:
3004909030
异氟醚合成路线
异氟醚上下游产品
异氟醚上游产品
异氟醚下游产品
异氟醚制备
2,2,2-三氟乙醇用硫酸二甲酯进行甲基化,生成2,2,2-三氟乙基甲基醚。经光照氯化生成2,2,2-三氟乙基二氯甲基醚和1-氯-2,2,2-三氟乙基二氯甲基醚的混合物。
其中1-氯-2,2,2-三氟乙基二氯甲基醚直接氟化即可得异氟烷。
另一化合物,即2,2,2-三氟乙基二氯甲基醚经氟化后.再氯化也可得异氟烷。
异氟醚海关
[ 海关编码 ]: 2909199090
[ 中文概述 ]:
2909199090. 其他无环醚及其卤化衍生物(包括磺化,硝化或亚硝化衍生物). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%
异氟醚文献
Stroke 46(3) , 835-42, (2015)
Ischemic stroke has been shown to cause hypermetabolism of glucose in the ischemic penumbra. Experimental and clinical data indicate that infarct-related systemic hyperglycemia is a potential therapeu...
Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPK.EMBO J. 34(3) , 275-93, (2015)
Numerous extrinsic and intrinsic insults trigger the HSF1-mediated proteotoxic stress response (PSR), an ancient transcriptional program that is essential to proteostasis and survival under such condi...
Detailed characterization of a long-term rodent model of critical illness and recovery.Crit. Care Med. 43(3) , e84-96, (2015)
To characterize a long-term model of recovery from critical illness, with particular emphasis on cardiorespiratory, metabolic, and muscle function.Randomized controlled animal study.University researc...
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公司名:上海化源世纪贸易有限公司
区域:上海市普陀区
价格:
联系人:徐经理
产品详情:异氟醚
公司名:上海吉至生化科技有限公司
区域:上海市奉贤区
价格:
¥758.0/25g
¥198.0/5g
联系人:刘佳
产品详情:异氟醚
公司名:上海源溪生物科技有限公司
区域:上海市浦东新区
价格:
¥需询单/1g
联系人:赖经理
产品详情:Isoflurane
公司名:上海脉铂医药科技有限公司
区域:上海市嘉定区
价格:
¥489.0/50mg
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¥需询单/1g
联系人:李先生
产品详情:Isoflurane
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥871.9/100g
¥311.9/25g
¥82.9/5g
¥43.9/1g
联系人:阿拉丁
产品详情:1-氯-2,2,2-三氟乙基二氟甲基醚
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相关化合物
【异氟醚】化源网提供异氟醚CAS号26675-46-7,异氟醚MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询异氟醚上化源网,专业又轻松。>>电脑版:异氟醚
标题:异氟醚_MSDS_用途_密度_异氟醚CAS号【26675-46-7】_化源网 地址:https://www.chemsrc.com/amp/cas/26675-46-7_511753.html