SB-668875

SB-668875用途

OX2 orexin受体的新型选择性肽激动剂。与在OX2 orexin受体上具有同等作用的Orexins A和B相比，具有优势。食欲素可引起突触后膜的直接和可逆去极化。 A novel, selective peptide agonist at OX2 orexin receptors. Possesses advantages over Orexins A and B which are equipotent at OX2 orexin receptors. The orexins can cause direct and reversible depolarisation of the postsynaptic membrane.

SB-668875名称

[ CAS 号 ]:
274252-40-3

[ 英文名 ]:
SB-668875

[英文别名 ]:

SB-668875
MFCD11045864

SB-668875物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 分子式 ]:
C₁₂₀H₂₀₆N₄₄O₃₅S

[ 分子量 ]:
2857.26

[ 精确质量 ]:
2855.541260

[ LogP ]:
-10.70

[ 折射率 ]:
1.670

[ 储存条件 ]:
-20°C储存

SB-668875安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

SB-668875文献

Pharmacological characterisation of the orexin receptor subtype mediating postsynaptic excitation in the rat dorsal raphe nucleus.

Neuropharmacology 46 , 1168-1176, (2004)

Electrophysiological recordings from dorsal raphe nucleus (DRN) neurones in rat brain slices have revealed that the orexins can cause direct and reversible depolarisation of the postsynaptic membrane....

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