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1,12-二氨基十二烷

1,12-二氨基十二烷用途

N12N is a polyamine inverse agonist of NMDA receptor.

1,12-二氨基十二烷名称

[ CAS 号 ]:
2783-17-7

[ 中文名 ]:
1,12-二氨基十二烷

[ 英文名 ]:
1,12-Diaminododecane

[中文别名 ]:

[英文别名 ]:

1,12-dodecadiamine
1,12-DODECANEDIAME
Diaminododecane
1,12-diaminododecyl
DODECANEDIAMINE
1,12-dodecamethylenediamine
RARECHEM AL BW 0116
Dodecamethylendiamin
dodecane-1,12-diamine
dodecyldiamine

1,12-二氨基十二烷物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
274.9±8.0 °C at 760 mmHg

[ 熔点 ]:
67-69 °C(lit.)

[ 分子式 ]:
C₁₂H₂₈N₂

[ 分子量 ]:
200.364

[ 闪点 ]:
155.0±0.0 °C

[ 精确质量 ]:
200.225250

[ PSA ]:
52.04000

[ LogP ]:
3.23

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.465

[ 储存条件 ]:
存放于惰性气体之中;避免空气

[ 水溶解性 ]:
可溶于：乙醇

1,12-二氨基十二烷MSDS

1,12-二氨基十二烷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JR2200000

CHEMICAL NAME :: 1,12-Dodecanediamine

CAS REGISTRY NUMBER :: 2783-17-7

BEILSTEIN REFERENCE NO. :: 1742765

LAST UPDATED :: 199710

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C12-H28-N2

MOLECULAR WEIGHT :: 200.42

WISWESSER LINE NOTATION :: Z12Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,92,1990 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 670 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,92,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1088 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 43(5),18,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 330 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 43(5),18,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 440 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 43(5),18,1978 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 54600 ug/kg/26W-I

TOXIC EFFECTS :: Endocrine - changes in thymus weight Blood - change in clotting factors Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 43(5),18,1978

1,12-二氨基十二烷安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H314-H317

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
C: Corrosive;

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 3259 8/PG 3

[ WGK德国 ]:
1

[ RTECS号 ]:
JR2200000

[ 包装等级 ]:
I; II; III

[ 危险类别 ]:
8.0

[ 海关编码 ]:
2921290000

1,12-二氨基十二烷合成路线

1,12-二氨基十二烷海关

[ 海关编码 ]: 2921290000

[ 中文概述 ]:
2921290000. 其他无环多胺及其衍生物及它们的盐. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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