Polyestradiol
Polyestradiol名称
[ CAS 号 ]:
28014-46-2
[ 英文名 ]:
Polyestradiol
[英文别名 ]:
- POLYOESTRIOLPHOSPATE
- oestradiol phosphate polymer
- POLYOESTRIOLPHOSPHATE
- POLYOESTRADIOLPHOSPHATE
Polyestradiol物理化学性质
[ 沸点 ]:
445.9ºC at 760mmHg
[ 分子式 ]:
C18H24O8P2
[ 分子量 ]:
430.32600
[ 闪点 ]:
209.6ºC
[ 精确质量 ]:
430.09500
[ PSA ]:
131.14000
[ LogP ]:
4.46930
[ 蒸汽压 ]:
9.82E-09mmHg at 25°C
Polyestradiol毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KG5792000
- CHEMICAL NAME :
- Estradiol, polyester with phosphoric acid
- CAS REGISTRY NUMBER :
- 28014-46-2
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 5
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and Toxicology. (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii, Kiev, USSR) No.1- 1964- Volume(issue)/page/year: 15,56,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and Toxicology. (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii, Kiev, USSR) No.1- 1964- Volume(issue)/page/year: 15,56,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 39 gm/kg/26W-I
- TOXIC EFFECTS :
- Liver - other changes Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and Toxicology. (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii, Kiev, USSR) No.1- 1964- Volume(issue)/page/year: 15,56,1980 ** TUMORIGENIC DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 173 mg/kg/9Y-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
- REFERENCE :
- ACLRBL Annals of Clinical Research. (Finnish Medical Soc., Duodecim, Runeberginkatu 47A, SF-00260 Helsinki 26, Finland) V.1- 1969- Volume(issue)/page/year: 7,287,1975 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 50 mg/kg
- SEX/DURATION :
- female 19 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - urogenital system
- REFERENCE :
- ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 33,520,1960
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相关化合物
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