7-氯-5-(2-氯苯基)-1,3-二氢-2-氧代-2H-1,4-苯并二氮杂卓-3-基乙酸酯

[ 密度 ]:
1.45 g/cm3

[ 沸点 ]:
524.4ºC at 760 mmHg

[ 分子式 ]:
C₁₇H₁₂Cl₂N₂O₃

[ 分子量 ]:
363.19500

[ 闪点 ]:
270.9ºC

[ 精确质量 ]:
362.02200

[ PSA ]:
67.76000

[ LogP ]:
3.24570

[ 蒸汽压 ]:
4.33E-11mmHg at 25°C

[ 折射率 ]:
1.656

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H410

[ 警示性声明 ]:
P273-P501

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

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Stereoselective binding of 3-acetoxy-, and 3-hydroxy-1,4-benzodiazepine-2-ones to human serum albumin. Selective allosteric interaction with warfarin enantiomers.

Biochem. Pharmacol. 35(2) , 263-9, (1986)

Stereoselective binding of oxazepam, lorazepam, temazepam and methyl lorazepam as well as of their acetates to human serum albumin was investigated by different techniques. The 2'-chlorine and the N(1...

Stereoselective kinetics of warfarin binding to human serum albumin: effect of an allosteric interaction.

Chirality 14(5) , 442-8, (2002)

Kinetic and equilibrium binding studies were performed on the interaction of warfarin enantiomers with human serum albumin (HSA) in the absence and presence of lorazepam acetate (LoAc) enantiomers. Bi...

Stereoselective allosteric binding interaction on human serum albumin between ibuprofen and lorazepam acetate.

Chirality 11(2) , 115-20, (1999)

The effect of ibuprofen enantiomers on the stereoselective binding of 3-acyloxy-1,4-benzodiazepines to human serum albumin (HSA) was studied using both native and Sepharose-immobilized protein. (S)-Lo...

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