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氰代磷酸二乙酯

氰代磷酸二乙酯用途

【用途一】
有机合成中间体。
【用途二】
多肽缩合剂[1]，酚羟基磷酸化试剂[2]，含羧基化合物进行HPLC分析时制备荧光衍生物时的活化剂。

氰代磷酸二乙酯名称

[ CAS 号 ]:
2942-58-7

[ 中文名 ]:
氰基磷酸二乙酯

[ 英文名 ]:
Diethyl Cyanophosphonate

[中文别名 ]:

[英文别名 ]:

diethylphosphoric cyanide
Diethyl cyanophosphosphonate
Cyanophosphonic Acid Diethyl Ester
Diethylcyanophosphonate
Diethylcyanophosphate
diethoxyphosphoryl cyanide
Diethyl phosphorocyanidate
Diethyl phosphoryl cyanide
MFCD00010256
Diethyl cyanidophosphate

氰代磷酸二乙酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
214.2±9.0 °C at 760 mmHg

[ 分子式 ]:
C₅H₁₀NO₃P

[ 分子量 ]:
163.112

[ 闪点 ]:
80.6±0.0 °C

[ 精确质量 ]:
163.039825

[ PSA ]:
69.13000

[ LogP ]:
0.04

[ 外观性状 ]:
液体;Colorless to Light yellow to Light orange clear liquid

[ 蒸汽压 ]:
0.2±0.4 mmHg at 25°C

[ 折射率 ]:
1.416

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
DECOMPOSES

氰代磷酸二乙酯MSDS

氰代磷酸二乙酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TD2500000

CHEMICAL NAME :: Phosphorocyanidic acid, O,O-diethyl ester

CAS REGISTRY NUMBER :: 2942-58-7

BEILSTEIN REFERENCE NO. :: 1768938

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C5-H10-N-O3-P

MOLECULAR WEIGHT :: 163.13

WISWESSER LINE NOTATION :: NCPO&O2&O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PAREAQ Pharmacological Reviews. (Williams & Wilkins, 428 E. Preston St., Baltimore, MD 21202) V.1- 1949- Volume(issue)/page/year: 11,636,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

REFERENCE :: JCSOA9 Journal of the Chemical Society. (London, UK) 1926-65. For publisher information, see JCPRB4. Volume(issue)/page/year: -,699,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

REFERENCE :: JCSOA9 Journal of the Chemical Society. (London, UK) 1926-65. For publisher information, see JCPRB4. Volume(issue)/page/year: -,699,1948 *** REVIEWS *** TOXICOLOGY REVIEW CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924- Volume(issue)/page/year: 48,225,1951

氰代磷酸二乙酯安全信息

[ 符号 ]:

GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300 + H310 + H330-H314

[ 补充危害声明 ]:
Contact with acids liberates very toxic gas.

[ 警示性声明 ]:
P260-P264-P280-P284-P301 + P310-P302 + P350

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T+:Verytoxic;C:Corrosive;

[ 风险声明 (欧洲) ]:
R26/27/28;R32;R34

[ 安全声明 (欧洲) ]:
S26-S36-S45-S50A-S36/37/39-S28A

[ 危险品运输编码 ]:
UN 2922 8/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
TD2500000

[ 包装等级 ]:
II

[ 危险类别 ]:
8

[ 海关编码 ]:
2931900090

氰代磷酸二乙酯合成路线

氰代磷酸二乙酯上下游产品

氰代磷酸二乙酯上游产品

氰代磷酸二乙酯下游产品

氰代磷酸二乙酯制备

将过量的溴化氰滴入二乙酯中，反应夜逐渐变热。反应毕，减压蒸馏，收集104-105°馏分，得氰基磷酸二乙酯。

氰代磷酸二乙酯海关

[ 海关编码 ]: 2931900090

[ 中文概述 ]:
2931900090. 其他有机-无机化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:6.5%. 普通关税:30.0%

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

氰代磷酸二乙酯文献

[Exploitation of new synthetic reagents and their application to the total synthesis of biologically active natural products].

Yakugaku Zasshi 108(12) , 1115-28, (1988)

Amino acids and peptides. XXXI. Phosphorus in organic synthesis. XVIII. Synthesis of porcine motilin by the solid-phase method using diphenyl phosphorazidate(DPPA) and diethyl phosphorocyanidate(DEPC).

Chem. Pharm. Bull. 28(11) , 3347-56, (1980)

Precolumn fluorescence tagging reagent for carboxylic acids in high-performance liquid chromatography: 4-substituted-7-aminoalkylamino-2,1,3-benzoxadiazoles.

J. Chromatogr. A. 588 , 61, (1991)

Four new 2,1,3-benzoxadiazole amine reagents having different functional groups at the 4- and 7-positions, [4-nitro-7-N-piperazino-2,1,3-benzoxadiazole (NBD-PZ), 4-(N,N-dimethylaminosulphonyl)-7-N-pip...

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