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辅酶Q9

辅酶Q9用途

Coenzyme Q9是含9个异戊二烯基的泛素,是人血浆的正常成分。

辅酶Q9名称

[ CAS 号 ]:
303-97-9

[ 中文名 ]:
辅酶Q9

[ 英文名 ]:
ubiquinone-9

[中文别名 ]:

[英文别名 ]:

ubiquinone-9
Ubidecarenone impurity D
Coenzyme Q9
Coenzyme Q9
Ubiquinone Q(sub 9)
CoQ(sub 9)
Coenzyme Q(sub 9)
All-Trans Coenzyme Q9
CoQ9
ubiquinone Q9

辅酶Q9生物活性

[ 描述 ]:

Coenzyme Q9是含9个异戊二烯基的泛素,是人血浆的正常成分。

[ 相关类别 ]:

研究领域 >> 心血管疾病

天然产物 >> 醌类

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

辅酶Q9和辅酶Q10都具有同样的心脏保护作用,这可以通过它们改善左心室功能和减少心肌梗塞面积和心肌细胞凋亡的能力得到证实。 HPLC分析显示大部分CoQ9已转化为CoQ10 [1]。辅酶Q10和辅酶Q9是哺乳动物线粒体呼吸链的组成部分,可以调节一些线粒体蛋白质/功能。大豆,玉米和菜籽油是CoQ10的非常丰富的来源,而在玉米油中发现了高浓度的CoQ9 [2]。

[体内研究]

在纯合CoQ9突变体(CoQ9(X/X))小鼠中缺乏功能性CoQ9蛋白导致CoQ7蛋白的严重减少和广泛的CoQ缺乏和去甲氧基醌的积累。 CoQ缺乏会导致线粒体生物能量学表现的脑特异性损伤,呼吸控制率降低,ATP水平和ATP/ADP比率以及呼吸复合物I的特定损失。这些影响导致神经元死亡和脱髓鞘,伴有严重的空泡化和星形胶质细胞增生。在CoQ9(X/X)小鼠的大脑中,因此在3至6个月大的时候死亡[3]。

[参考文献]

[1]. Lekli I, et al. Coenzyme Q9 provides cardioprotection after converting into coenzyme Q10. J Agric Food Chem. 2008 Jul 9;56(13):5331-7.

[2]. Venegas C, et al. Determination of coenzyme Q10, coenzyme Q9, and melatonin contents in virgin argan oils: comparison with other edible vegetable oils. J Agric Food Chem. 2011 Nov 23;59(22):12102-8.

[3]. García-Corzo L, et al. Dysfunctional Coq9 protein causes predominant encephalomyopathy associated with CoQ deficiency. Hum Mol Genet. 2013 Mar 15;22(6):1233-48.

[相关活性小分子]

辅酶Q9物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
826.8±65.0 °C at 760 mmHg

[ 熔点 ]:
41-43ºC

[ 分子式 ]:
C₅₄H₈₂O₄

[ 分子量 ]:
795.227

[ 闪点 ]:
314.4±34.3 °C

[ 精确质量 ]:
794.621338

[ PSA ]:
52.60000

[ LogP ]:
18.89

[ 蒸汽压 ]:
0.0±3.0 mmHg at 25°C

[ 折射率 ]:
1.525

[ 储存条件 ]:
-20°C

辅酶Q9MSDS

详细MSDS(安全技术说明书)

辅酶Q9毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DK4786000

CHEMICAL NAME :: p-Benzoquinone, 2,3-dimethoxy-5-methyl-6-(3,7,11,15,19,23,27,31,35-no namethyl-2,6,10,14,18, 22,26,30,34-hexatriacontanonaenyl)-

CAS REGISTRY NUMBER :: 303-97-9

BEILSTEIN REFERENCE NO. :: 1900081

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C54-H82-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,147,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >800 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,147,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >600 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,147,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >250 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,147,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,147,1969

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,147,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1500 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,147,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,147,1969 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11250 mg/kg/45D-C

TOXIC EFFECTS :: Gastrointestinal - other changes Liver - changes in liver weight Endocrine - changes in spleen weight

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 3,147,1969

辅酶Q9安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
DK4786000

辅酶Q9合成路线

详细合成路线

辅酶Q9上下游产品

辅酶Q9上游产品

辅酶Q9下游产品

辅酶Q9文献

A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity.

Nat. Cell Biol. 17 , 782-92, (2015)

The coordinated regulation of mitochondrial and nuclear activities is essential for cellular respiration and its disruption leads to mitochondrial dysfunction, a hallmark of ageing. Mitochondria commu...

Rapid high performance liquid chromatography-high resolution mass spectrometry methodology for multiple prenol lipids analysis in zebrafish embryos.

J. Chromatogr. A. 1412 , 59-66, (2015)

The analysis of lipid molecules in living organism is an important step in deciphering metabolic pathways. Recently, the zebrafish has been adopted as a valuable animal model system to perform in vivo...

Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis.

Biochim. Biophys. Acta 1841(7) , 977-86, (2014)

2,3-Oxidosqualene is an intermediate in cholesterol biosynthesis and 2,3:22,23-dioxidosqualene act as the substrate for an alternative pathway that produces 24(S),25-epoxycholesterol which effects cho...

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