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α-(4-Chlorophenyl)-2-methyl-N-2-pyridinyl-1H-indole-3-methanamine

用途

CCT036477 is a selective inhibitor of wingless-type MMTV integration site family (WNT)-dependent transcription. It reduces the transcriptional activity of the T-cell factor/lymphoid enhancer factor transcription factor family at the ?-catenin level.

名称

[ CAS 号 ]:
305372-78-5

[ 中文名 ]:
α-(4-Chlorophenyl)-2-methyl-N-2-pyridinyl-1H-indole-3-methanamine

[ 英文名 ]:
CCT036477

[英文别名 ]:

物理化学性质

[ 分子式 ]:
C21H18ClN3

[ 分子量 ]:
347.84100

[ 精确质量 ]:
347.11900

[ PSA ]:
40.71000

[ LogP ]:
5.79920

MSDS

安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

文献

Targeting Wnt pathway in mantle cell lymphoma-initiating cells.

J. Hematol. Oncol. 8 , 63, (2015)

Mantle cell lymphoma (MCL) is an aggressive and incurable form of non-Hodgkin's lymphoma. Despite initial intense chemotherapy, up to 50% of cases of MCL relapse often in a chemoresistant form. We hyp...


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相关化合物

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