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4-氯-5-氨磺酰邻氨基苯甲酸

4-氯-5-氨磺酰邻氨基苯甲酸名称

[ CAS 号 ]:
3086-91-7

[ 中文名 ]:
4-氯-5-氨磺酰邻氨基苯甲酸

[ 英文名 ]:
4-Chloro-5-sulfamoylanthranilic Acid

[英文别名 ]:

4-Chloro-5-sulfamoylanthranilic acid
2-AMINO-5-AMINOSULFONYL-4-CHLOROBENZOIC ACID
4-chloro-5-sulphamoyl anthranilic acid
Desfurylmethylfurosemide
Saluamine
2-amino-4-chloro-5-sulfamoyl-benzoic acid
Furosemide Related Compound B
EINECS 221-408-7
4-chloro-5-sulfamoyl-anthranilic acid
4-Chloro-5-sulfanilanthranilic acid

4-氯-5-氨磺酰邻氨基苯甲酸物理化学性质

[ 密度 ]:
1.726g/cm3

[ 沸点 ]:
549.2ºC at 760mmHg

[ 熔点 ]:
267°C (dec.) (lit.)

[ 分子式 ]:
C₇H₇ClN₂O₄S

[ 分子量 ]:
250.65900

[ 闪点 ]:
286ºC

[ 精确质量 ]:
249.98200

[ PSA ]:
131.86000

[ LogP ]:
2.63010

[ 外观性状 ]:
固体

[ 折射率 ]:
1.665

[ 储存条件 ]:
室温

4-氯-5-氨磺酰邻氨基苯甲酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P305 + P351 + P338

[ 危害码 (欧洲) ]:
N

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2935009090

4-氯-5-氨磺酰邻氨基苯甲酸合成路线

详细合成路线

4-氯-5-氨磺酰邻氨基苯甲酸上下游产品

4-氯-5-氨磺酰邻氨基苯甲酸上游产品

4-氯-5-氨磺酰邻氨基苯甲酸下游产品

4-氯-5-氨磺酰邻氨基苯甲酸海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

4-氯-5-氨磺酰邻氨基苯甲酸文献

The use of HPLC to elucidate the metabolism and urinary excretion of furosemide and its metabolic products.

Acta Pharmacol. Toxicol. (Copenh.) 49(3) , 223-9, (1981)

Three principles for the use of HPLC with spectrophotometric detection to determine the concentration of furosemide and of 4-chloro-5-sulfamoyl anthranilic acid (CSA) were studied. A reversed phase mi...

The binding of furosemide to serum proteins in elderly patients: displacing effect of phenprocoumon.

Acta Pharmacol. Toxicol. (Copenh.) 47(3) , 202-7, (1980)

The percentual binding of furosemide (5 micrograms/ml) was slightly but significantly lower in serum from elderly patients than in serum from normal blood donors (96.5 +/- 0.7 versus 97.9 +/- 0.3). A ...

Furosemide accelerates gentamicin accumulation in cultured renal cells (LLC-PK1 cells).

Nephron 53(2) , 138-41, (1989)

Furosemide is known to potentiate gentamicin nephrotoxicity. The mechanism of potentiation is unclear. In our previous studies, we demonstrated that furosemide enhanced gentamicin accumulation in rabb...

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