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多沙普仑

多沙普仑用途

Doxapram能抑制TASK-1,TASK-3和TASK-1/TASK-3异二聚体通道,EC50分别为410 nM,37 μM和9 μM。

多沙普仑名称

[ CAS 号 ]:
309-29-5

[ 中文名 ]:
多沙普仑

[ 英文名 ]:
Doxapram

[中文别名 ]:

吗乙苯吡酮

[英文别名 ]:

Doxapramum
Dopram
Doxapram HCL
doxapram
UNII:94F3830Q73
doxapram hydrochloride

多沙普仑生物活性

[ 描述 ]:

Doxapram能抑制TASK-1,TASK-3和TASK-1/TASK-3异二聚体通道,EC50分别为410 nM,37 μM和9 μM。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钾通道

研究领域 >> 神经疾病

[参考文献]

[1]. Cotten JF, et al. The ventilatory stimulant doxapram inhibits TASK tandem pore (K2P) potassium channel function but does not affect minimum alveolar anesthetic concentration. Anesth Analg, 2006, 102(3), 779-785.

[2]. Peers, C., Effects of doxapram on ionic currents recorded in isolated type I cells of the neonatal rat carotid body. Brain Res, 1991. 568(1-2): p. 116-22.

[3]. Anderson-Beck, R., et al., Doxapram stimulates dopamine release from the intact rat carotid body in vitro. Neurosci Lett, 1995. 187(1): p. 25-8.

[相关活性小分子]

多沙普仑物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
536.4±50.0 °C at 760 mmHg

[ 分子式 ]:
C₂₄H₃₀N₂O₂

[ 分子量 ]:
378.507

[ 闪点 ]:
278.2±30.1 °C

[ 精确质量 ]:
378.230713

[ PSA ]:
32.78000

[ LogP ]:
3.23

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.562

[ 储存条件 ]:
-20℃

多沙普仑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY5769500

CHEMICAL NAME :: 2-Pyrrolidinone, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-

CAS REGISTRY NUMBER :: 309-29-5

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C24-H30-N2-O2

MOLECULAR WEIGHT :: 378.56

WISWESSER LINE NOTATION :: T6N DOTJ A2- DT5NVTJ A2 CR& CR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 268 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)

REFERENCE :: JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 30,522,1978 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 1800 ug/kg

SEX/DURATION :: female 16 week(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - other effects to embryo

REFERENCE :: BJOGAS British Journal of Obstetrics and Gynaecology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.82- 1975- Volume(issue)/page/year: 84,48,1977

多沙普仑安全信息

[ 海关编码 ]:
2934999090

多沙普仑合成路线

详细合成路线

多沙普仑海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%