三光气

三光气用途

【用途一】
用于合成氯甲酸酯、异氰酸酯、聚碳酸酯和酰氯等
【用途二】
⑴ 医药合成：用于氯甲酸酯、异氰酸酯、聚碳酸酯、酰氯等精细化学品及阿洛西林、美洛西林、派拉西林及依那普利、降压等药物的合成。是生产抗生素类及其它药物的重要中间体。⑵ 农药制造：用于制造氨基甲酸酯类农药、脲类除草剂、合成除草剂、杀虫剂。⑶ 高分子材料合成：是合成聚氨酯类泡沫塑料的重要原料。

三光气名称

[ CAS 号 ]:
32315-10-9

[ 中文名 ]:
二(三氯甲基)碳酸酯

[ 英文名 ]:
Triphosgene

[中文别名 ]:

[英文别名 ]:

MFCD00062848
tri-Phosgene
Bis(trichloromethyl) carbonate
ditrichloromethyl carbonate
Triphosgene
Bis(trichloromethyl)carbonate
trichloromethyl carbonate
bistrichloromethyl carbonate
EINECS 250-986-3

三光气物理化学性质

[ 密度 ]:
1.9±0.1 g/cm3

[ 沸点 ]:
204.5±0.0 °C at 760 mmHg

[ 熔点 ]:
79-83 °C(lit.)

[ 分子式 ]:
C₃Cl₆O₃

[ 分子量 ]:
296.748

[ 闪点 ]:
53.3±26.3 °C

[ 精确质量 ]:
293.797852

[ PSA ]:
35.53000

[ LogP ]:
4.02

[ 外观性状 ]:
透明液体

[ 蒸汽压 ]:
0.3±0.4 mmHg at 25°C

[ 折射率 ]:
1.533

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
practically insoluble

三光气MSDS

三光气安全信息

[ 符号 ]:

GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314-H330

[ 警示性声明 ]:
P260-P280-P284-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+:Verytoxic;

[ 风险声明 (欧洲) ]:
R26;R29;R34

[ 安全声明 (欧洲) ]:
S36/37/39-S45-S9-S26

[ 危险品运输编码 ]:
UN 2928 6.1/PG 2

[ WGK德国 ]:
2

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29209010

三光气合成路线

三光气上下游产品

三光气上游产品

三光气下游产品

三光气制备

在装有冷凝管的250ml三口瓶中，加入18g(0.5mol)碳酸二甲酯和100ml四氯化碳，瓶外用俩只125W自镇流高压汞灯泡照射。在搅拌下通入干燥的氯气。反应放热，温度逐渐上升并使溶液回流，逸出的氯化氢气体用碱液（20% Na2CO3溶液）吸收。通氯约15h，反应溶液变稠且过量氯气的黄绿色不再消失。停止通氯，冷至室温，用N2驱除过量的氯，在水泵减压下蒸除溶剂，冷至室温，残余物固化。真空干燥，得无色晶体59g,产率99%，mp79~81℃

三光气海关

[ 海关编码 ]: 2920909090

[ 中文概述 ]:
2920909090 其他无机酸酯（不包括卤化氢的酯）（包括其盐及它们的卤化，磺化，硝化和亚硝化衍生物）。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2920909090 esters of other inorganic acids of non-metals (excluding esters of hydrogen halides) and their salts; their halogenated, sulphonated, nitrated or nitrosated derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

三光气文献

Multi-modal transfection agent based on monodisperse magnetic nanoparticles for stem cell gene delivery and tracking.

Biomaterials 35(25) , 7239-47, (2014)

Directing the controlled differentiation and tracking of stem cells is essential to achieve successful stem cell therapy. In this work, we describe a multi-modal (MR/optical) transfection agent (MTA) ...

Poly(anhydride-ester) and poly(N-vinyl-2-pyrrolidone) blends: salicylic acid-releasing blends with hydrogel-like properties that reduce inflammation.

Macromol. Biosci. 15(3) , 342-50, (2015)

Polymers such as poly(N-vinyl-2-pyrrolidone) (PVP) have been used to prepare hydrogels for wound dressing applications but are not inherently bioactive. For enhanced healing, PVP was blended with sali...

Ultrasound-Triggered Phase-Transition Cationic Nanodroplets for Enhanced Gene Delivery.

ACS Appl. Mater. Interfaces 7 , 13524-37, (2015)

Ultrasound as an external stimulus for enhanced gene transfection represents a safe, noninvasive, cost-effective delivery strategy for gene therapy. Herein, we have developed an ultrasound-triggered p...

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三光气