利谷隆

利谷隆用途

【用途一】
属脲类除草剂，可用于大豆、玉米、棉花、胡萝卜、芹菜、小麦、花生、甘蔗、果树等作物
【用途二】
利谷隆可用于玉米、小麦、棉花、大豆、高粱、花生、豌豆、马铃薯、陆稻、向日葵、甘蔗、亚麻以及多种蔬菜和果树、森林苗圃等作物田中防治种利单、双子叶杂草以及某此多年生杂草。大白鼠口服LD为4000mg/kg。
【用途三】
利谷隆可用于玉米、小麦、棉花、大豆、高粱、花生、豌豆、马铃薯、陆稻、向日葵、甘蔗、亚麻以及多种蔬菜和果树、森林苗圃等作物田中防治种利单、双子叶杂草以及某此多年生杂草。

利谷隆名称

[ CAS 号 ]:
330-55-2

[ 中文名 ]:
利谷隆

[ 英文名 ]:
Linuron

[中文别名 ]:

[英文别名 ]:

Lorex
EINECS 206-356-5
3-(3,4-Dichlorophenyl)-1-methoxy-1-methylurea
Linuron
Laroks
Urea, N'-(3,4-dichlorophenyl)-N-methoxy-N-methyl-
AFALON
LOROX
MFCD00055249
Afolan

利谷隆生物活性

[ 描述 ]:

Linuron 是一种苯基脲除草剂,广泛用于控制各种农作物和果园中草和杂草的生长。Linuron 是一种光系统 II 抑制剂。Linuron 也是一种竞争性雄激素受体 (AR) 拮抗剂,Ki 为 100 μM,在动物体内表现出生殖毒性,可作为内分泌干扰物。

[ 相关类别 ]:

研究领域 >> 内分泌

信号通路 >> 其他 >> 雄激素受体

[ 靶点 ]

Ki: 100 μM (Androgen receptor)[2] Photosystem II[4]

[参考文献]

[1]. Benjamin Horemans, et al. Functional Redundancy of Linuron Degradation in Microbial Communities in Agricultural Soil and Biopurification Systems. Appl Environ Microbiol. 2016 Apr 18;82(9):2843-2853.

[2]. C Lambright, et al. Cellular and Molecular Mechanisms of Action of Linuron: An Antiandrogenic Herbicide That Produces Reproductive Malformations in Male Rats. Toxicol Sci. 2000 Aug;56(2):389-99.

[3]. Hongwei Ding, et al. Reproductive Toxicity of Linuron Following Gestational Exposure in Rats and Underlying Mechanisms. Toxicol Lett. 2017 Jan 15;266:49-55.

[4]. Elżbieta G Magnucka, et al. Various Effects of the Photosystem II--inhibiting Herbicides on 5-n-alkylresorcinol Accumulation in Rye Seedlings. Pestic Biochem Physiol. 2014 Nov;116:56-62.

利谷隆物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
361.7±52.0 °C at 760 mmHg

[ 熔点 ]:
93-94°C

[ 分子式 ]:
C₉H₁₀Cl₂N₂O₂

[ 分子量 ]:
249.094

[ 闪点 ]:
172.6±30.7 °C

[ 精确质量 ]:
248.011932

[ PSA ]:
41.57000

[ LogP ]:
3.33

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.556

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 水溶解性 ]:
0.0075 g/100 mL

利谷隆MSDS

详细MSDS(安全技术说明书)

利谷隆毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YS9100000

CHEMICAL NAME :: Urea, 3-(3,4-dichlorophenyl)-1-methoxy-1-methyl-

CAS REGISTRY NUMBER :: 330-55-2

LAST UPDATED :: 199710

DATA ITEMS CITED :: 23

MOLECULAR FORMULA :: C9-H10-Cl2-N2-O2

MOLECULAR WEIGHT :: 249.11

WISWESSER LINE NOTATION :: GR BG DMVN1&O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1146 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 48 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 3765 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg/60D-C

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1070 mg/kg/31W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 10 gm/kg/10D-I

TOXIC EFFECTS :: Cardiac - EKG changes not diagnostic of specified effects Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 7500 mg/kg/30D-I

TOXIC EFFECTS :: Behavioral - muscle weakness Cardiac - EKG changes not diagnostic of specified effects Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 1750 mg/kg/7D-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Related to Chronic Data - death

TYPE OF TEST :: DNA damage

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,353,1978 *** REVIEWS *** TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3 JAN 1993

利谷隆安全信息

[ 符号 ]:

GHS07, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H351-H360Df-H373-H410

[ 警示性声明 ]:
P201-P273-P281-P308 + P313-P501

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
N,T,F

[ 风险声明 (欧洲) ]:
R61

[ 安全声明 (欧洲) ]:
S53-S45-S60-S61-S36/37

[ 危险品运输编码 ]:
UN 3077

[ RTECS号 ]:
YS9100000

[ 海关编码 ]:
2928000032

利谷隆合成路线

详细合成路线

利谷隆上下游产品

利谷隆上游产品

利谷隆下游产品

利谷隆制备

由3，4-二氯苯异氰酸酯与硫酸羟胺反应生成3，4-二氯苯羟基脲，然后与硫酸二甲酯反应制得利谷隆。1.3，4-二氯苯羟基脲的制备将3，4-二氯苯异氰酸酯-甲苯溶液、硫酸羟胺水溶液、氢氧化钠溶液按计算量分别抽入各计量槽。将水和硫酸羟胺同时加入搪玻璃反应锅，搅拌冷却，在20℃左右开始滴加氢氧化钠溶液，约1h滴完，温度控制在20℃左右，滴加完毕pH在7.5-7.9之间（否则补加氢氧化钠或硫酸羟胺）。然后开始滴加3，4-二氯苯异氰酸酯-甲苯溶液，此时控制温度30±2℃，约1.5h内滴完，并在此温度下继续反应2h。静置2h后，将上层甲苯清液抽出。下层物料加水搅拌后进行离心分离，得固体湿品3，4-二氯苯羟基脲。收率87%。2.利谷隆的制备将上述湿品羟基脲加入搪坡璃反应釜，然后加入计算量的硫酸二甲酯，搅拌20min。滴加20%的氢氧化钠溶液，温度控制在20-30℃，约1.5h内滴加完毕。在30℃左右反应2h，至pH7为反应终点，若偏酸性时，可适当补加氢氧化钠。反应结束后加水搅拌，甩滤，干燥，即得利谷隆原粉。收率90%。

利谷隆海关

[ 海关编码 ]: 2928000032

[ 中文概述 ]:
2928000032 绿谷隆、溴谷隆、利谷隆、氯溴隆。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:20.0%

[ Summary ]:
2928000032 3-(4-bromo-3-chlorophenyl)-1-methoxy-1-methylurea。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

利谷隆文献

LC-MS analysis of the plasma metabolome--a novel sample preparation strategy.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 978-979 , 83-8, (2015)

Blood plasma is a well-known body fluid often analyzed in studies on the effects of toxic compounds as physiological or chemical induced changes in the mammalian body are reflected in the plasma metab...

Occurrence and distribution of sulfonylurea and related herbicides in central Canadian surface waters 2006-2008.

Bull. Environ. Contam. Toxicol. 87(4) , 420-5, (2011)

Surface water sampling in 2006-2008 measured the occurrence of sulfonylureas and related herbicides (SUs) during base flow conditions and wet weather events. Flumetsulam (29.2%), diuron (36.5%) and fo...

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

J. Med. Chem. 51 , 6740-51, (2008)

The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared ...

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利谷隆