1,10-Decanediol,2,2,9,9-tetramethyl-

1,10-Decanediol,2,2,9,9-tetramethyl-用途

吉利二醇是一种强效的抗脂剂。吉利二醇具有研究高脂蛋白血症的潜力[1][2]。

1,10-Decanediol,2,2,9,9-tetramethyl-名称

[ CAS 号 ]:
35449-36-6

[ 英文名 ]:
1,10-Decanediol,2,2,9,9-tetramethyl-

[英文别名 ]:

Gemcadiol
2,2,9,9-tetramethyl-decane-1,10-diol
2,2,9,9-Tetramethyl-1,10-decanediol
CI-720
2,2,9,9-Tetramethyl-1,10-decandiol
2,2,9,9-Tetramethyl-decan-1,10-diol

1,10-Decanediol,2,2,9,9-tetramethyl-生物活性

[ 描述 ]:

吉利二醇是一种强效的抗脂剂。吉利二醇具有研究高脂蛋白血症的潜力[1][2]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[体内研究]

二甲二醇(25-300 mg/kg；13周) 降低猴子的血清胆固醇并略微增加血清肌酸磷酸激酶[2]

[参考文献]

[1]. Blumethal HP, et al. Gemcadiol: a new antilipemic drug, a clinical trial. Lipids. 1977 Jan;12(1):44-8.

[2]. Fitzgerald JE, et al. Preclinical toxicology studies with the lipid-regulating agent gemcadiol. Fundam Appl Toxicol. 1986 Apr;6(3):520-31.

1,10-Decanediol,2,2,9,9-tetramethyl-物理化学性质

[ 密度 ]:
0.904g/cm3

[ 沸点 ]:
319.3ºC at 760mmHg

[ 分子式 ]:
C₁₄H₃₀O₂

[ 分子量 ]:
230.39

[ 闪点 ]:
136.7ºC

[ 精确质量 ]:
230.22500

[ PSA ]:
40.46000

[ LogP ]:
3.36400

[ 折射率 ]:
1.461

1,10-Decanediol,2,2,9,9-tetramethyl-毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HD8452000

CHEMICAL NAME :: 1,10-Decanediol, 2,2,9,9-tetramethyl-

CAS REGISTRY NUMBER :: 35449-36-6

BEILSTEIN REFERENCE NO. :: 1748265

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C14-H30-O2

MOLECULAR WEIGHT :: 230.44

WISWESSER LINE NOTATION :: Q1X1&1&6X1&1&1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1023 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,520,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0064286

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1023 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,520,1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10920 mg/kg/52W-C

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,520,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 109 gm/kg/52W-I

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,520,1986 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,520,1986

1,10-Decanediol,2,2,9,9-tetramethyl-安全信息

[ 海关编码 ]:
2905399090

1,10-Decanediol,2,2,9,9-tetramethyl-合成路线

详细合成路线

1,10-Decanediol,2,2,9,9-tetramethyl-上下游产品

1,10-Decanediol,2,2,9,9-tetramethyl-上游产品

1,10-Decanediol,2,2,9,9-tetramethyl-下游产品

1,10-Decanediol,2,2,9,9-tetramethyl-海关

[ 海关编码 ]: 2905399090

[ 中文概述 ]:
2905399090 其他二元醇。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2905399090 other diols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%