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L-Glutamic acid,N-[4-[[2-(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)ethyl]amino]benzoyl]- (9CI)

名称

[ CAS 号 ]:
3566-25-4

[ 英文名 ]:
L-Glutamic acid,N-[4-[[2-(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)ethyl]amino]benzoyl]- (9CI)

[英文别名 ]:

Homofolsaeure
Homofolate

物理化学性质

[ 密度 ]:
1.64g/cm3

[ 分子式 ]:
C₂₀H₂₁N₇O₆

[ 分子量 ]:
455.42400

[ 精确质量 ]:
455.15500

[ PSA ]:
213.28000

[ LogP ]:
1.04280

[ 折射率 ]:
1.744

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA0601000

CHEMICAL NAME :: Glutamic acid, N-(p-((2-(2-amino-4-hydroxy-6-pteridinyl)ethyl)amino) benzoyl)-

CAS REGISTRY NUMBER :: 3566-25-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C20-H21-N7-O6

MOLECULAR WEIGHT :: 455.48

WISWESSER LINE NOTATION :: T66 BN DN GN JNJ CZ EQ H2MR DVMYVQ2VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 12800 ug/kg

SEX/DURATION :: female 8-9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - live birth index (measured after birth)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 400 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

REFERENCE :: LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 14,1541,1974