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2-噻吩乙酰氯

2-噻吩乙酰氯用途

【用途一】
用作医药中间体
【用途二】
先锋霉素Ⅰ、Ⅱ，头孢类多种药物中间体。

2-噻吩乙酰氯名称

[ CAS 号 ]:
39098-97-0

[ 中文名 ]:
2-噻吩乙酰氯

[ 英文名 ]:
2-Thiopheneacetyl chloride

[中文别名 ]:

[英文别名 ]:

2-Thiophene Acetyl Chloride
EINECS 254-290-0
Thiophene-2-acetyl Chloride
2-(2-thienyl)acetyl chloride
2-Thiopheneacetyl chloride
Thiophen-2-ylacetylchlorid
2-Thienylacetyl chloride
2-(Thiophen-2-yl)acetyl chloride
MFCD00005456

2-噻吩乙酰氯物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
202.4±0.0 °C at 760 mmHg

[ 分子式 ]:
C₆H₅ClOS

[ 分子量 ]:
160.621

[ 闪点 ]:
88.7±22.6 °C

[ 精确质量 ]:
159.974960

[ PSA ]:
45.31000

[ LogP ]:
1.91

[ 外观性状 ]:
透明棕色液体

[ 蒸汽压 ]:
0.3±0.4 mmHg at 25°C

[ 折射率 ]:
1.563

[ 储存条件 ]:
2-8°C

2-噻吩乙酰氯MSDS

2-噻吩乙酰氯安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314-H335

[ 补充危害声明 ]:
Reacts violently with water.

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R14;R29;R34

[ 安全声明 (欧洲) ]:
S26-S28-S36/37/39-S45-S8-S30-S23

[ 危险品运输编码 ]:
UN 3265 8/PG 2

[ WGK德国 ]:
3

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
29349990

2-噻吩乙酰氯合成路线

2-噻吩乙酰氯上下游产品

2-噻吩乙酰氯上游产品

2-噻吩乙酰氯下游产品

2-噻吩乙酰氯制备

【方法一】
由2-噻吩乙酸与氯化亚砜反应则得。将2-噻吩乙酸和氯化亚砜加入搪玻璃反应锅内，用40-50℃水浴加热反应4h，反应液进行减压蒸馏，除去剩的氯化亚砜和低沸物后，收集160℃（0.67kPa）馏分，即得2-噻吩乙酰氯。

2-噻吩乙酰氯海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-噻吩乙酰氯文献

Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides.

Bioorg. Med. Chem. 22(17) , 4968-97, (2014)

TTK kinase was identified by in-house siRNA screen and pursued as a tractable, novel target for cancer treatment. A screening campaign and systematic optimization, supported by computer modeling led t...

Design and synthesis of a beta-lactamase activated 5-fluorouracil prodrug.

Bioorg. Med. Chem. Lett. 19(4) , 1261-3, (2009)

An efficient synthesis of a 5-fluorouracil-cephalosporin prodrug is described for use against colorectal and other cancers in antibody and gene-directed therapies. The compound shows stability in aque...

Synthesis and biological evaluation of some 6-arylamidomorphines as analogues of morphine-6-glucuronide.

Bioorg. Med. Chem. 12(22) , 5983-90, (2004)

A series of 6-beta-arylamidomorphines was synthesized and biologically evaluated. Various aryl substituents were introduced into the arylamidomorphines to examine substituent structure-activity relati...

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