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氯乙酸钠

氯乙酸钠用途

【用途一】
用于医药、化工等
【用途二】
用于染料合成，还用作除草剂
【用途三】
用于合成染料、农药除草剂等
【用途四】
用于农药、医药等有机合成中。
【用途五】
有机合成。药用。除草剂。染料。

氯乙酸钠名称

[ CAS 号 ]:
3926-62-3

[ 中文名 ]:
一氯醋酸钠

[ 英文名 ]:
Sodium chloroacetate

[中文别名 ]:

[英文别名 ]:

sodium 2-chloroacetate
Chloroacetic acid, sodium salt
Sodium monochloroacetate
SMA
Acetic acid, 2-chloro-, sodium salt (1:1)
Chloroacetic acid sodium salt
EINECS 223-498-3
Sodium chloroacetate
sodium,2-chloroacetate
MFCD00002684

氯乙酸钠物理化学性质

[ 密度 ]:
1.399g/cm3

[ 沸点 ]:
189ºC at 760 mmHg

[ 熔点 ]:
199 °C (dec.)(lit.)

[ 分子式 ]:
C₂H₂ClNaO₂

[ 分子量 ]:
116.479

[ 闪点 ]:
270°C

[ 精确质量 ]:
115.964104

[ PSA ]:
40.13000

[ 外观性状 ]:
白色粉末

[ 折射率 ]:
1.438

[ 储存条件 ]:
库房通风低温干燥,与碱类、氧化剂分开存放

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
440 g/L (20 ºC)

氯乙酸钠MSDS

氯乙酸钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AG1400000

CHEMICAL NAME :: Acetic acid, chloro-, sodium salt

CAS REGISTRY NUMBER :: 3926-62-3

LAST UPDATED :: 199710

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C2-H2-Cl-O2.Na

MOLECULAR WEIGHT :: 116.48

WISWESSER LINE NOTATION :: QV1G &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 95 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,78,1941

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 165 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 86,336,1946

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 156 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS) Volume(issue)/page/year: -,1047,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 99 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,78,1941

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 115 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 31(12),53,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 81 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS) Volume(issue)/page/year: -,1047,1966

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Gastrointestinal - hypermotility, diarrhea Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: NVTMAF Nordisk Veterinaermedicin Danske Udgave. (Copenhagen, Denmark) Volume(issue)/page/year: 13,271,1961

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - domestic

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - coma Gastrointestinal - other changes

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 18,179,1961 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5400 mg/kg/90D-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in leukocyte (WBC) count

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 67,171,1991

氯乙酸钠安全信息

[ 符号 ]:

GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H315-H319-H400

[ 警示性声明 ]:
P273-P301 + P310-P305 + P351 + P338

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R25;R38;R50

[ 安全声明 (欧洲) ]:
S22-S37-S45-S61

[ 危险品运输编码 ]:
UN 2659 6.1/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
AG1400000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2915400090

氯乙酸钠合成路线

氯乙酸钠上下游产品

氯乙酸钠上游产品

氯乙酸钠下游产品

氯乙酸钠制备

由氯乙酸与氢氧化钠（或碳酸钠）反应而得。将氯乙酸溶解于无水乙醇中，冷却至20℃以下，慢慢加入氢氧化钠饱和溶液。反应完毕，冷却析出结晶。过滤，用乙醇洗涤，减压蒸馏，干燥而得成品。一般有机合成中只需要氯乙酸钠的水溶液。在这种情况下，将氯乙酸水溶液和碳酸钠于70℃反应，使反应pH为6.8-7，即得所需的氯乙酸钠溶液。

氯乙酸钠海关

[ 海关编码 ]: 2915400010

[ 中文概述 ]:
2915400010 一氯醋酸钠。监管条件:无。增值税率:17.0%。退税率:0.0%。最低关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2915400010 sodium 2-chloroacetate。Supervision conditions:None。VAT:17.0%。Tax rebate rate:0.0%。Lowest tariff:5.5%。General tariff:30.0%

氯乙酸钠文献

Mammalian cell cytotoxicity and genotoxicity of the haloacetic acids, a major class of drinking water disinfection by-products.

Environ. Mol. Mutagen. 51(8-9) , 871-8, (2010)

The haloacetic acids (HAAs) are disinfection by-products (DBPs) that are formed during the disinfection of drinking water, wastewaters and recreational pool waters. Currently, five HAAs [bromoacetic a...

Chloroacetic acid triggers apoptosis in neuronal cells via a reactive oxygen species-induced endoplasmic reticulum stress signaling pathway.

Chem. Biol. Interact. 225 , 1-12, (2015)

Chloroacetic acid (CA), a chlorinated analog of acetic acid and an environmental toxin that is more toxic than acetic, dichloroacetic, or trichloroacetic acids, is widely used in chemical industries. ...

Ultrasensitive electrochemical immunoassay for avian influenza subtype H5 using nanocomposite.

PLoS ONE 9(4) , e94685, (2014)

We report a novel electrochemical immunosensor that can sensitively detect avian influenza virus H5 subtype (AIV H5) captured by graphene oxide-H5-polychonal antibodies-bovine serum albumin (GO-PAb-BS...

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