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培磷酰胺

培磷酰胺用途

4-氢过氧基环磷酰胺是前药环磷酰胺的活性代谢产物。4-氢过氧环磷酰胺交联DNA,诱导T细胞凋亡,不依赖死亡受体激活,但通过产生活性氧(ROS)激活线粒体死亡途径。4-氢过氧环磷酰胺用于治疗淋巴瘤和自身免疫性疾病。

培磷酰胺名称

[ CAS 号 ]:
39800-16-3

[ 中文名 ]:
培磷酰胺

[ 英文名 ]:
4-Hydroperoxy cyclophosphamide

[中文别名 ]:

4-过氧羟基环磷酰胺

[英文别名 ]:

PERFOSFAMIDE
ASTA 6496
4-Hydroperoxycyclofosfamide
4-Hydroperoxycyclophosphamide
4-OOH Cyclophosphamide
Perfosphamide
4-Hydroperoxy-cyclophosphamid

培磷酰胺生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

信号通路 >> 细胞周期/DNA损伤 >> DNA烷基化剂/交联剂

培磷酰胺物理化学性质

[ 密度 ]:
1.465g/cm3

[ 沸点 ]:
419.946ºC at 760 mmHg

[ 熔点 ]:
100-103ºC

[ 分子式 ]:
C₇H₁₅Cl₂N₂O₄P

[ 分子量 ]:
293.08500

[ 闪点 ]:
207.776ºC

[ 精确质量 ]:
292.01500

[ PSA ]:
80.84000

[ LogP ]:
2.02850

[ 折射率 ]:
1.525

[ 储存条件 ]:
-20°C，密闭，干燥

培磷酰胺MSDS

详细MSDS(安全技术说明书)

培磷酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RP5900000

CHEMICAL NAME :: 2H-1,3,2-Oxazophosphorine, 2-(bis(2-chloroethyl)amino)-4-hydroperoxytetrahydro-, 2-oxide

CAS REGISTRY NUMBER :: 39800-16-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C7-H15-Cl2-N2-O4-P

MOLECULAR WEIGHT :: 293.11

WISWESSER LINE NOTATION :: T6MPOTJ BN2G2G FOQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 76040 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 5 mg/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 35,1163,1986