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阿朴吗啡

阿朴吗啡用途

【用途一】
本品是一种催吐药物。

阿朴吗啡名称

[ CAS 号 ]:
41372-20-7

[ 中文名 ]:
阿朴吗啡

[ 英文名 ]:
R-(-)-Apomorphine

[中文别名 ]:

(R)-(-)-阿朴吗啡盐酸盐半水

[英文别名 ]:

(R)-Apomorphine Hydrochloride Hemihydrate
EINECS 206-243-0
R-(-)-Apomorphine
Apomorphine hydrochloride hemihydrate
MFCD00150904
R-(−)-Apomorphine hydrochloride hemihydrate
Apomorphine (hydrochloride hemihydrate)

阿朴吗啡物理化学性质

[ 密度 ]:
1.299 g/cm3

[ 沸点 ]:
473.4ºC at 760 mmHg

[ 熔点 ]:
285-287 °C(lit.)

[ 分子式 ]:
C₁₇H₂₀ClNO₃

[ 分子量 ]:
321.79900

[ 闪点 ]:
268.8ºC

[ 精确质量 ]:
321.11300

[ PSA ]:
52.93000

[ LogP ]:
3.52550

[ 外观性状 ]:
灰色结晶粉末

阿朴吗啡MSDS

详细MSDS(安全技术说明书)

阿朴吗啡安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

阿朴吗啡制备

由吗啡经消除、重排、成盐而得。将吗啡加入磷酸中，水浴加热，内温不超过50℃。搅拌至全溶。冷却置于吸收罐内，通入氯化氢气体至反应液重达吗啡量的2.5倍。将其移入反应罐内，继续通入氯化氢气体，同时加热至124-126℃，保温反应3小时。将反应液放入冰水中，冷至20℃以下，搅拌下慢慢加入碳酸钠至胶状物析出完全为止。分取胶状物加入浓盐酸中，在沸水中溶解胶状物盐酸盐，再加入亚硫酸钠溶液中，用二氯乙烷-异丙醇混合溶媒提取2次。提取液于搅拌下加入浓盐酸，析出粗品。将所得粗品用浓盐酸浸泡、热蒸馏水溶解、加活性炭脱色、真空干燥等步骤便得到成品。

阿朴吗啡文献

Modulation of 5-lipoxygenase in proteotoxicity and Alzheimer's disease.

J. Neurosci. 33(25) , 10512-25, (2013)

The accumulation of intracellular β amyloid (Aβ) may be one of the factors leading to neuronal cell death in Alzheimer's disease (AD). Using a pyrazole called CNB-001, which was selected for its abili...

Activation of serotonin2A receptors in the medial septum-diagonal band of Broca complex enhanced working memory in the hemiparkinsonian rats.

Neuropharmacology 91 , 23-33, (2015)

Serotonin2A (5-HT2A) receptors are highly expressed in the medial septum-diagonal band of Broca complex (MS-DB), especially in parvalbumin (PV)-positive neurons linked to hippocampal theta rhythm, whi...

Effects of prolonged neuronal nitric oxide synthase inhibition on the development and expression of L-DOPA-induced dyskinesia in 6-OHDA-lesioned rats.

Neuropharmacology 89 , 87-99, (2014)

It is well known that nitric oxide (NO) interacts with dopamine (DA) within the striatal circuitry. The anti-dyskinetic properties of NO synthase (NOS) inhibitors demonstrate the importance of NO in L...

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