N6-环戊基腺苷酸

N6-环戊基腺苷酸用途

N6-Cyclopentyladenosine (CPA) 是一个选择性的腺苷A3 受体 (Adenosine A1 receptor)的激动剂,其对人A1、A2A 和 A3 受体的Ki 分别为 2.3 nM、790 nM 和 43 nM。

N6-环戊基腺苷酸名称

[ CAS 号 ]:
41552-82-3

[ 中文名 ]:
N6-环戊基腺苷酸

[ 英文名 ]:
N6-Cyclopentyladenosine

[中文别名 ]:

N6-环戊基TYLADENOSINE

[英文别名 ]:

N6-Cyclopentyladenosine

N6-环戊基腺苷酸生物活性

[ 描述 ]:

N6-Cyclopentyladenosine (CPA) 是一个选择性的腺苷A3 受体 (Adenosine A1 receptor)的激动剂,其对人A1、A2A 和 A3 受体的Ki 分别为 2.3 nM、790 nM 和 43 nM。

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体

[ 靶点 ]

Ki: 2.3 nM (A1), 790 nM (A2A), 43 nM(A3)[1].

[参考文献]

[1]. Klotz KN, et al. Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362(4-5):382-91.

[2]. Soliño M, et al. Adenosine A1 receptor: A neuroprotective target in light induced retinal degeneration. PLoS One. 2018 Jun 18;13(6):e0198838.

N6-环戊基腺苷酸物理化学性质

[ 密度 ]:
1.78g/cm3

[ 沸点 ]:
673.4ºC at 760 mmHg

[ 分子式 ]:
C₁₅H₂₁N₅O₄

[ 分子量 ]:
335.36

[ 闪点 ]:
361.1ºC

[ 精确质量 ]:
335.15900

[ PSA ]:
125.55000

[ 折射率 ]:
1.816

[ 储存条件 ]:
2-8℃

N6-环戊基腺苷酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

N6-环戊基腺苷酸合成路线

详细合成路线

N6-环戊基腺苷酸上下游产品

N6-环戊基腺苷酸上游产品

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N6-环戊基腺苷酸文献

The effect of pH and ion channel modulators on human placental arteries.

PLoS ONE 9(12) , e114405, (2014)

Chorionic plate arteries (CPA) are located at the maternofetal interface where they are able to respond to local metabolic changes. Unlike many other types of vasculature, the placenta lacks nervous c...

Acid-sensing ion channel 3 decreases phosphorylation of extracellular signal-regulated kinases and induces synoviocyte cell death by increasing intracellular calcium.

Arthritis. Res. Ther. 16(3) , R121, (2014)

Acid-sensing ion channel 3 (ASIC3) is expressed in synoviocytes, activated by decreases in pH, and reduces inflammation in animal models of inflammatory arthritis. The purpose of the current study was...

Chemoenzymatic Syntheses of Sialylated Oligosaccharides Containing C5-Modified Neuraminic Acids for Dual Inhibition of Hemagglutinins and Neuraminidases.

Chemistry 21 , 10903-12, (2015)

A fast chemoenzymatic synthesis of sialylated oligosaccharides containing C5-modified neuraminic acids is reported. Analogues of GM3 and GM2 ganglioside saccharidic portions where the acetyl group of ...

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