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L-亮氨酸-4-硝基苯胺

L-亮氨酸-4-硝基苯胺用途

【用途一】
光谱测定亮氨酸氨基肽酶(aminopeptidase)的发光底物，比如来自于气单胞菌(Aeromonas）嗜热脂肪芽孢杆菌(Bacillus stearothermophilus）、猪肾脏和酵母中的氨基肽酶。

L-亮氨酸-4-硝基苯胺名称

[ CAS 号 ]:
4178-93-2

[ 中文名 ]:
L-亮氨酸-4-硝基苯胺

[ 英文名 ]:
N-(4-Nitrophenyl)-L-leucinamide

[英文别名 ]:

MFCD00063681
EINECS 224-047-3
N-(4-Nitrophenyl)-L-leucinamide
h-leu-pna

L-亮氨酸-4-硝基苯胺物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
454.5±30.0 °C at 760 mmHg

[ 熔点 ]:
88-90ºC

[ 分子式 ]:
C₁₂H₁₇N₃O₃

[ 分子量 ]:
251.282

[ 闪点 ]:
228.7±24.6 °C

[ 精确质量 ]:
251.126984

[ PSA ]:
100.94000

[ LogP ]:
1.83

[ 外观性状 ]:
结晶,无色液体

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.589

[ 储存条件 ]:
2-8°C

L-亮氨酸-4-硝基苯胺MSDS

L-亮氨酸-4-硝基苯胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317-H319

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36

[ 安全声明 (欧洲) ]:
S26-S36-S37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2924299090

L-亮氨酸-4-硝基苯胺合成路线

L-亮氨酸-4-硝基苯胺上下游产品

L-亮氨酸-4-硝基苯胺上游产品

L-亮氨酸-4-硝基苯胺下游产品

L-亮氨酸-4-硝基苯胺海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

L-亮氨酸-4-硝基苯胺文献

Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18.

PLoS ONE 10(2) , e0115859, (2015)

Malaria is a parasitic disease that remains a global health burden. The ability of the parasite to rapidly develop resistance to therapeutics drives an urgent need for the delivery of new drugs. The M...

Beta-phenyl cysteine: a leucine aminopeptidase inhibitor.

Pharmacol. Res. Commun. 16(6) , 533-8, (1984)

Beta-phenyl cysteine: a leucine aminopeptidase inhibitor. The kinetic parameters of the inhibition of the leucine aminopeptidase by beta-phenyl cysteine are reported in this communication.

Exploration of structural and physicochemical requirements and search of virtual hits for aminopeptidase N inhibitors.

Mol. Divers. 17(1) , 123-37, (2013)

Aminopeptidase N (APN) inhibitors have been reported to be effective in treating of life threatening diseases including cancer. Validated ligand- and structure-based pharmacophore mapping approaches w...

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